Results 31 to 40 of about 261,577 (311)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

New science, drug regulation, and emergent public health issues: The work of FDA’s division of applied regulatory science

Frontiers in Medicine, 2023
The U.S. Food and Drug Administration (FDA) Division of Applied Regulatory Science (DARS) moves new science into the drug review process and addresses emergent regulatory and public health questions for the Agency.
Kimberly Chiu, Rebecca Racz, Keith Burkhart, Jeffry Florian, Kevin Ford, M. Iveth Garcia, Robert M. Geiger, Kristina E. Howard, Paula L. Hyland, Omnia A. Ismaiel, Naomi L. Kruhlak, Zhihua Li, Murali K. Matta, Kristin W. Prentice, Kristin W. Prentice, Aanchal Shah, Aanchal Shah, Lidiya Stavitskaya, Donna A. Volpe, James L. Weaver, Wendy W. Wu, Rodney Rouse, David G. Strauss   +22 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Multi-Laboratory Validation of a Loop-Mediated Isothermal Amplification Method for Screening Salmonella in Animal Food

Frontiers in Microbiology, 2019
Loop-mediated isothermal amplification (LAMP) has gained wide popularity in the detection of Salmonella in foods owing to its simplicity, rapidity, and robustness.
Beilei Ge, Kelly J. Domesle, Qianru Yang, Thomas S. Hammack, Shizhen S. Wang, Xiaohong Deng, Lijun Hu, Guodong Zhang, Yuan Hu, Xiaokuang Lai, Kyson X. Chou, Jan Ryan Dollete, Kirsten A. Hirneisen, Sammie P. La, Richelle S. Richter, Diyo R. Rai, Azadeh A. Yousefvand, Paul K. Park, Cindy H. Wu, Tameji Eames, David Kiang, Ju Sheng, Dancia Wu, Lori Hahn, Lisa Ledger, Cynthia Logie, Qiu You, Durda Slavic, Hugh Cai, Sherry L. Ayers, Shenia R. Young, Ruiqing Pamboukian   +31 more
doaj   +1 more source

An Outbreak Investigation of Salmonella Typhimurium Illnesses in the United States Linked to Packaged Leafy Greens Produced at a Controlled Environment Agriculture Indoor Hydroponic Operation – 2021

Journal of Food Protection, 2023
In 2021, the U.S. Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), and state partners investigated a multistate outbreak of Salmonella Typhimurium illnesses linked to packaged leafy greens from a controlled ...
Monica McClure, Brooke Whitney, Ifueko Gardenhire, Alvin Crosby, Allison Wellman, Kane Patel, Zachary D. McCormic, Laura Gieraltowski, Lauren Gollarza, Mabel S.F. Low, Jennifer Adams, Arthur Pightling, Rebecca L. Bell, Kurt Nolte, Mary Tijerina, Joseph T. Frost, James A. Beix, Karen A. Boegler, Julie Dow, Shana Altman, Matthew E. Wise, Michael C. Bazaco, Stelios Viazis   +22 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Paired metagenomic and chemical evaluation of aflatoxin-contaminated dog kibble

Frontiers in Veterinary Science
IntroductionIdentification of chemical toxins from complex or highly processed foods can present ‘needle in the haystack’ challenges for chemists. Metagenomic data can be used to guide chemical toxicity evaluations by providing DNA-based description of ...
Andrea Ottesen, Brandon Kocurek, Elizabeth Reed, Seth Commichaux, Mark Mammel, Padmini Ramachandran, Patrick McDermott, Brenna M. Flannery, Errol Strain   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Veterinary Laboratory Investigation and Response Network: 15 Years of Promoting Human and Animal Health by Collaborating with the Veterinary Diagnostic Laboratory Community

Journal of Food Protection
The Veterinary Laboratory Investigation and Response Network (Vet-LIRN), a collaborative network established in 2010, is a partnership between the Food and Drug Administration’s Center for Veterinary Medicine (FDA CVM) and 48 veterinary diagnostic ...
Sarah M. Nemser, Olgica Ceric, Jake Guag, Sarah Pauley, Angelica Jones, Kathleen Proia, Megan R Miller, Andriy Tkachenko, David Rotstein, April Hodges, Renate Reimschuessel, Gregory H. Tyson   +11 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source