Results 51 to 60 of about 787,943 (334)

Rheumatic and musculoskeletal adverse events with immune checkpoint inhibitors: Data from the United States Food and Drug Administration adverse event reporting system

Journal of Immunotherapy and Precision Oncology, 2019
Background: Despite their efficacy, immune checkpoint inhibitors (ICIs) can cause significant immune-related adverse events (irAEs). Rheumatic and musculoskeletal irAEs can be serious and adversely affect the quality of life.
X. Pundole, M. Sarangdhar, M. Suarez‐Almazor   +2 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A network of regulatory innovations to improve FDA quality assessments of human drug applications

International Journal of Pharmaceutics: X
A network of regulatory innovations brings a holistic approach to improving the submission, assessment, and lifecycle management of pharmaceutical quality information in the U.S. This dedicated effort in the FDA’s Center for Drug Evaluation and Research (
Russie Tran, Grace Fraser, Adam C. Fisher, Sau L. Lee, Ashley Boam, Stelios Tsinontides, Jennifer Maguire, Lawrence X. Yu, Susan Rosencrance, Steven Kozlowski, Don Henry   +10 more
doaj   +1 more source

Global Environmental Law: Food Safety & China [PDF]

, 2013
This article makes the case for food security law and policy as a component of global environmental law in recognition of the global economy, trade liberalization, and concerns for food safety and environmental harm. It further describes rule of law as a
Czarnezki, Jason J.
core   +1 more source

Targeting Angiogenesis in Cancer Therapy [PDF]

, 2011
Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a ...
Ichihara, Eiki, Kiura, Katsuyuki, Tanimoto, Mitsune   +2 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The Veterinary Laboratory Investigation and Response Network: 15 Years of Promoting Human and Animal Health by Collaborating with the Veterinary Diagnostic Laboratory Community

Journal of Food Protection
The Veterinary Laboratory Investigation and Response Network (Vet-LIRN), a collaborative network established in 2010, is a partnership between the Food and Drug Administration’s Center for Veterinary Medicine (FDA CVM) and 48 veterinary diagnostic ...
Sarah M. Nemser, Olgica Ceric, Jake Guag, Sarah Pauley, Angelica Jones, Kathleen Proia, Megan R Miller, Andriy Tkachenko, David Rotstein, April Hodges, Renate Reimschuessel, Gregory H. Tyson   +11 more
doaj   +1 more source

A Comprehensive Evaluation of the Genetic Relatedness of Listeria monocytogenes Serotype 4b Variant Strains

Frontiers in Public Health, 2017
Recently, we have identified a link between four listeriosis incidents/outbreaks to a variant of Listeria monocytogenes (Lm) serotype 4b strains, 4bV.
Laurel S. Burall, Christopher J. Grim, Mark K. Mammel, Atin R. Datta   +3 more
doaj   +1 more source

Targeting cancer with antibody-drug conjugates: Promises and challenges

mAbs, 2021
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the U.S.
Alexis Q. Dean, Shen Luo, Julianne D. Twomey, Baolin Zhang   +3 more
doaj   +1 more source

"The United States Food and Drug Administration: Its role, authority, history, harmonization activities, and cooperation with the European Union." [PDF]

, 1997
The purpose of this article is to provide background about the United States Food and Drug Administration (FDA). The article will focus particularly upon the agency's authority, its place in the United States system, and its history as a domestic ...
Horton, Linda.
core