Results 51 to 60 of about 478,778 (207)

United States Food and Drug Administration approved oral kinase inhibitors for the treatment of malignancies [PDF]

Current Problems in Cancer, 2013
The United States Food and Drug Administration (FDA) has approved 19 oral kinase inhibitors (KIs) for the treatment of malignancies in hematology and oncology as of May 2013, see Table 1. We review the general principles and guidelines for using KIs for cancer treatment. This article is not designed for cross-trial comparison or to make recommendations
Woondong Jeong, James H. Doroshow, Shivaani Kummar   +2 more
openaire   +3 more sources

PD-L1 Mediates IFNγ-Regulation of Glucose but Not of Tryptophan Metabolism in Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2022
The immune checkpoint programmed death-ligand 1 (PD-L1) is expressed on the cell surface of tumor cells and is key for maintaining an immunosuppressive microenvironment through its interaction with the programmed death 1 (PD-1).
Mamatha Garige, Susmita Ghosh, Alexis Norris, Guangyuan Li, Sarah Poncet, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Carole Sourbier   +8 more
doaj   +1 more source

The acquired pco gene cluster in Salmonella enterica mediates resistance to copper

Frontiers in Microbiology
The pervasive environmental metal contamination has led to selection of heavy-metal resistance genes in bacteria. The pco and sil clusters are located on a mobile genetic element and linked to heavy-metal resistance.
Ahmed F. Hikal, Sameer Hasan, Dereje Gudeta, Shaohua Zhao, Steven Foley, Ashraf A. Khan   +5 more
doaj   +1 more source

The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model

Frontiers in Pharmacology
Preparations of black cohosh extract are sold as dietary supplements marketed to relieve the vasomotor symptoms of menopause, and some studies suggest it may protect against postmenopausal bone loss.
Amy L. Inselman, Elysia A. Masters, Jalina N. Moore, Rajiv Agarwal, Audrey Gassman, Gemma Kuijpers, Richard D. Beger, Kenneth B. Delclos, Sybil Swift, Luísa Camacho, Michelle M. Vanlandingham, Daniel Sloper, Noriko Nakamura, Gonçalo Gamboa da Costa, Kellie Woodling, Matthew Bryant, Raul Trbojevich, Qiangen Wu, Florence McLellen, Donna Christner   +19 more
doaj   +1 more source

Evaluation of a natural language processing tool for extracting gender, weight, ethnicity, and race in the US food and drug administration adverse event reporting system

Frontiers in Drug Safety and Regulation, 2022
The US Food and Drug Administration Adverse Event Reporting System (FAERS) contains over 24 million individual case safety reports (ICSRs). In this research project, we evaluated a natural language processing (NLP) tool’s ability to extract four ...
Vivian Dang, Eileen Wu, Cindy M. Kortepeter, Michael Phan, Rongmei Zhang, Yong Ma, Monica A. Muñoz   +6 more
doaj   +1 more source

Agricultural Practices Influence Salmonella Contamination and Survival in Pre-harvest Tomato Production

Frontiers in Microbiology, 2018
Between 2000 and 2010 the Eastern Shore of Virginia was implicated in four Salmonella outbreaks associated with tomato. Therefore, a multi-year study (2012–2015) was performed to investigate presumptive factors associated with the contamination of ...
Ganyu Gu, Laura K. Strawn, David O. Oryang, Jie Zheng, Elizabeth A. Reed, Andrea R. Ottesen, Rebecca L. Bell, Yuhuan Chen, Steven Duret, David T. Ingram, Mark S. Reiter, Rachel Pfuntner, Eric W. Brown, Steven L. Rideout   +13 more
doaj   +1 more source

Global Environmental Law: Food Safety & China [PDF]

, 2013
This article makes the case for food security law and policy as a component of global environmental law in recognition of the global economy, trade liberalization, and concerns for food safety and environmental harm. It further describes rule of law as a
Czarnezki, Jason J.
core   +1 more source

Balancing Consumer Protection and Scientific Integrity in the Face of Uncertainty: The Example of Gluten-Free Foods [PDF]

, 2010
In 2009, gluten-free foods were not only hot in the marketplace, several countries, including the United States, continued efforts to define gluten-free and appropriate labeling parameters.
McCabe, Margaret Sova
core   +1 more source

FDA’s new pharmaceutical quality initiative: Knowledge-aided assessment & structured applications

International Journal of Pharmaceutics: X, 2019
This paper describes a new FDA’s pharmaceutical quality assessment system: Knowledge-aided Assessment & Structured Application (KASA). The KASA system is designed to: 1) capture and manage knowledge during the lifecycle of a drug product; 2) establish ...
Lawrence X. Yu, Andre Raw, Larisa Wu, Christina Capacci-Daniel, Ying Zhang, Susan Rosencrance   +5 more
doaj  

The United States Food and Drug Administration's Approach to Training International Suppliers in Food Safety and Security [PDF]

HortTechnology, 2006
In 1998 the U.S. Food and Drug Administration (US-FDA) published formal guidelines for the microbial safety of fresh produce. The guidelines identify and suggest the use of good agricultural practices (GAP) and good manufacturing practices (GMP) for producers and handlers.
James W. Rushing, Christopher S. Walsh
openaire   +2 more sources