Results 71 to 80 of about 2,439,631 (288)

State of the art in the determination of the fine structure constant and the ratio $h/m_\mathrm{u}$

, 2019
The fine structure constant $\alpha$ and the ratio $h/m_{\mathrm{u}}$ between the Planck constant and the unified atomic mass are keystone constants for the determination of other fundamental physical constants, especially the ones involved in the ...
Biraben, François, Cladé, Pierre, Guellati-Khelifa, Saïda, Nez, François   +3 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Optimal µPMU Placement Considering Node Importance and Multiple Deployed Monitoring Devices in Distribution Networks

Energies
The placement of micro phasor measurement units in an active distribution network can improve the monitoring performance of the system. However, the price and placement cost of micro phasor measurement units are high, so existing research mostly focuses ...
Ruifeng Zhao, Jiangang Lu, Yizhe Chen, Yifan Gao, Kai Gan, Ming Li, Chengzhi Wei, Runhong Huang, Fan Xiao, Liang Che   +9 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Sequential Discrete Kalman Filter for Real-Time State Estimation in Power Distribution Systems: Theory and Implementation

, 2017
This paper demonstrates the feasibility of implementing Real-Time State Estimators (RTSEs) for Active Distribution Networks (ADNs) in Field-Programmable Gate Arrays (FPGAs) by presenting an operational prototype.
Kettner, Andreas Martin, Paolone, Mario
core   +1 more source

Phasor measurement units, WAMS, and their applications in protection and control of power systems

Journal of Modern Power Systems and Clean Energy, 2018
The paper provides a short history of the phasor measurement unit (PMU) concept. The origin of PMU is traced to the work on developing computer based distance relay using symmetrical component theory.
A. Phadke, T. Bi
semanticscholar   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Review of measured vibration and noise environments experienced by passengers in aircraft and in ground transportation systems [PDF]

, 1975
Measured vibration and interior noise data are presented for a number of air and surface vehicles. Consideration is given to the importance of direction effects; of vehicle operations such as take-off, cruise, and landing; and of measurement location on ...
Stephens, D. G.
core   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source