Results 161 to 170 of about 1,872,952 (282)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

P539: International policies guiding the identification, analysis, and management of secondary findings from genomic sequencing: Results from a systematic review

Genetics in Medicine Open
Safa Majeed, Christine Johnston, Saumeh Saeedi, Chloe Mighton, Vanessa Rokoszak, Ilham Abbasi, Sonya Grewal, Vernie Aguda, David Malkin, Yvonne Bombard   +9 more
doaj   +1 more source

Diverse platforms, diverse effects: Evidence from a 100-day study on social media and adolescent mental health. [PDF]

Curr Psychol
van der Wal A, Beyens I, Janssen LHC, Valkenburg PM.   +3 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Influence of Religious Commitment on Social Cognition: An Exploratory Study of Social Representations of Peace Among a Sample of Graduates Cameroonians. [PDF]

Eur J Psychol
Etoundi JC, Goujon B, Gaymard S.
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The integration of virtual reality and EEG: A step-by-step guideline. [PDF]

MethodsX
Krampe C, Wolfers J, Dean P.
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Semaglutide promotes bone marrow-derived progenitor cell flux towards an anti-inflammatory and pro-regenerative profile in high-risk patients: the SEMA-VR CardioLink-15 trial. [PDF]

Eur Heart J
Park B, Dennis F, He AZ, Krishnaraj A, Bakbak E, Dennis CJ, Pan Y, Misner E, Thayanithy V, Lambotharan B, Lambotharan V, Lambotharan A, Mazer CD, Quan A, Teoh H, Hess DA, Verma S.   +16 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source