Results 261 to 270 of about 1,895,243 (330)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Artificial Intelligence can transform formative assessment in medical education. [PDF]

Can Med Educ J
Feldman J, Gilchrist C, Leung FH.
europepmc   +1 more source

Game Development in Unity : Game Production, Game Mechanics and the Effects of Gaming

, 2013
Jason Dansie
openalex   +1 more source

Transparent porous films with real refractive index close to unity for photonic applications

José M. Miranda‐Muñoz, José María Viaña, Mauricio E. Calvo, Gabriel Lozano, Hernán Míguez   +4 more
openalex   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Substituent and Ring-Number Effects on the Kinetics of PAH + OH Reactions: A QSAR-DOE Approach with Tunneling Corrections. [PDF]

Molecules
Parzych C, Baradyn M, Ratkiewicz A.
europepmc   +1 more source

Unity in Diversity: A Stylistic Analysis of Ezenwa-Ohaeto’s The Voice of the Night Masquerade and Niyi Osundare’s The Word is an Egg a

, 2011
Uchenna Oyali
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Mapping the Imaginaire at the Frontiers of Science: The Quest for Universal Unity at the Turn of the Twentieth Century (Review Article)

, 2014
Vladislav Razdyakonov
openalex   +1 more source

A defensive model and implementation baseline for the metaverse and extended reality systems. [PDF]

PeerJ Comput Sci
Qamar S, Tahir H, Anwar Z, Ahmed N, Tahir S, Aleem M.   +5 more
europepmc   +1 more source