Results 141 to 150 of about 27,549 (267)

A novel methodology for localizing pallidal deep brain stimulation leads. [PDF]

Front Neuroanat
Pobiel B, O'Neill KJ, Patriat R, Palnitkar T, Hill ME, Cole RC, Braun H, Alberico SL, Mohanty B, Bauer D, Park MC, Cooper SE, Vitek JL, Harel N, Aman JE.   +14 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Multi-institutional MRI-based radiomic pilot study to measure the variations between scanner vendors and imaging sessions. [PDF]

Front Oncol
Duong S, Lee D, Glide-Hurst C, Paliwal B, Crosby J, Boss M, Cui Y, Huang M, Li H, Sheikh K, Kim T, Monroe J, Oh JH, Xiao Y, Sohn JW.   +14 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

iDT-diet: Toward Personalized Health Forecasting-An Intelligent Digital Twin Model for Diet-Influenced Biomarker Trajectories (Student Abstract). [PDF]

Proc AAAI Conf Artif Intell
Nobel A, Matos J, Wang H, Fang H.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

SimNav-XR: an extended reality platform for mobile robot simulation using ROS2 and Unity3D. [PDF]

Front Robot AI
Aryan P, Shetty SD, Kalaichelvi V, Karthikeyan R.   +3 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Design, development, and validation of a multimodal synergy-based intuitive virtual and augmented reality therapy platform for mental health. [PDF]

Front Robot AI
Olikkal P, Mebaghanje O, Janeja V, Sundharram S, Moharrer G, Ajendla A, Kleinsmith A, Clemmensen AS, Anguluri R, Culbreth A, Vinjamuri R.   +10 more
europepmc   +1 more source