Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
In vivo magnetic recording of neuronal action potentials using a differential TMR magnetrode. [PDF]
Wang Y +6 more
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
UNITY/Gonzalves Letter to Locatelli, March 30th, 1989
Letter from Rutherford S. Gonzalves on behalf of student group UNITY to Charles J. Beirne, S.J., and Paul L. Locatelli, S.J., dated March 30, 1989. The letter states that twenty-five students have "united…to reconvene the student group UNITY and to ...
Gonzalves, Rutherford S.
core
High-Performance Tri-Band Metamaterial Absorber for Polarization-Insensitive EMI Shielding in Microwave Communication Systems. [PDF]
Din IU, Khan D, Denidni TA.
europepmc +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Near-Unity Chiral Lasing Enabled by Quasi-Bound States in the Continuum. [PDF]
Mendoza-Carreño J +5 more
europepmc +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Spatially local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways. [PDF]
Chen Q, Rieke F.
europepmc +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source

