Results 151 to 160 of about 71,038 (298)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

A study on the moral autonomy of adolescents-an empirical analysis based on the third time national moral survey. [PDF]

Front Psychol
Chen Y, Wang J.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Social Unity and Individual Freedom [PDF]

-3- his life to a study of the history of science, opines that the crucial problem of our culture is the achievement of the advan- tages of social unity while enjoying at the same time the benefits of individual freedom.

core  

Implementing the screening for poverty and related social determinants and intervening to improve knowledge of and links to resources (SPARK) in primary care clinics across Canada. [PDF]

Fam Pract
Kosowan L, O'Rourke JJ, Howse D, Williams L, Adekoya I, Seshie AZ, Delahunty-Pike A, Smithman MA, Katz A, Abaga E, Zsager A, Cooney J, Robinson M, Senior DM, Aubrey-Bassler K, Marshall EG, Neudorf C, Muhajarine N, Fortuna I, Gupta A, Pinto AD.   +20 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Toward a paradox-oriented paradigm of knowing: the form theory of observation and quality in empirical sciences. [PDF]

Front Sociol
Staller MS, Koerner S.
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Respiratory syncytial virus infections and myocardial injury: the GEMINI Initiative. [PDF]

Eur Heart J
McAlister FA, Guo Y, Roberts SB, Verma AA.   +3 more
europepmc   +1 more source