Results 41 to 50 of about 930,155 (265)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Universal Peptidomimetics [PDF]
Journal of the American Chemical Society, 2010 This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics.
Eunhwa, Ko +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Pesquisa & psicanálise: algumas referências lacanianas
Psicologia: Teoria e PesquisaEste estudo propõe uma discussão sobre alguns dos parâmetros que orientam a pesquisa no campo da psicanálise, levando-se em conta que esta não se reconhece nos critérios estatísticos e experimentais do discurso da ciência.
Angela Cavalcanti Bernardes
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Estudios Eclesiásticos, 1945 A raíz de la voluminosa obra de investigación que Carlos Giacon, SJ dedicó a Guillermo de Ockam, en el capítulo final de la obra, Giacon recoge en una mirada sintética el rastro dejado por Ockam en la historia de la filosofía y sobre sus influjos en el ...
Jesús Iturrioz
doaj
Penentuan Fungsi Linear yang Ideal Pada Model Ekonomi Fungsi Penawaran
Eksis: Jurnal Riset Ekonomi dan Bisnis, 2018 Fenomena ekonomi yang kompleks karena hubungan antar variabel-variabel ekonomi dalam dunia nyata sangatlah kompleks. Fenomena tersebut menjadi sebuah model ekonomi dengan melakukan penyederhanaan.
Tonaas Kabul Wangkok Yohanis Marentek +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source