Results 41 to 50 of about 147,744 (304)

Universal Health Coverage in Low-Income Countries

, 2018
During the past decade, Tanzania has experienced steady economic growth, with average annual growth rates of between 6 and 7 percent.
Nicolas Rosemberg, Rosemberg, Nicolas, Huihui Wang, Wang, Huihui   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Setting research priorities for sexual, reproductive, maternal, newborn, child and adolescent health in humanitarian settings

Conflict and Health, 2021
Background An estimated 70.8 million people are forcibly displaced worldwide, 75% of whom are women and children. Prioritizing a global research agenda to inform guidance, service delivery, access to and quality of services is essential to improve the ...
Loulou Kobeissi, Mahalakshmi Nair, Egmond Samir Evers, Mansuk Daniel Han, Samira Aboubaker, Lale Say, Nigel Rollins, Gary L. Darmstadt, Karl Blanchet, Daniel Martinez Garcia, Olivier Hagon, Per Ashorn, Members of the WHO research prioritization group for SRMNCAH promotion in humanitarian settings   +12 more
doaj   +1 more source

Role of hospitals in recovery from COVID-19: Reflections from hospital managers and frontliners in the Eastern Mediterranean Region on strengthening hospital resilience

Frontiers in Public Health, 2023
BackgroundCOVID-19 highlighted the critical role that hospitals play throughout the prolonged response and continuous recovery stages of the pandemic. Yet, there is limited evidence related to hospitals in the recovery stage, particularly capturing the ...
Hamid Ravaghi, Merette Khalil, Jehan Al-Badri, Antoinette Vanessa Naidoo, Ali Ardalan, Hamidreza Khankeh, Hamidreza Khankeh   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Scaling up delivery of HIV services in Africa through harnessing trends across global emerging innovations

Frontiers in Health Services, 2023
Globally, innovations for HIV response present exciting opportunities to enhance the impact and cost-effectiveness of any HIV program. However, countries especially in the African region are not on equal footing to effectively harness some of the ...
Moredreck Chibi, William Wasswa, Chipo Nancy Ngongoni, Frank Lule   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The provision and utilization of essential health services in Afghanistan during COVID-19 pandemic

Frontiers in Public Health, 2023
IntroductionThe COVID-19 pandemic has disrupted provision of essential health services and overwhelmed even robust health systems worldwide. The Afghanistan health system has suffered both from the pandemic, as well as from political upheaval and regime ...
Narges Neyazi, Christina Lindan, Saber Perdes, Abdul Ghani Ibrahimi, Dirk Horemans, Deena Al Afsoor   +5 more
doaj   +1 more source

Addressing Inequity to Achieve the Maternal and Child Health Millennium Development Goals: Looking Beyond Averages. [PDF]

, 2012
Inequity in access to and use of child and maternal health interventions is impeding progress towards the maternal and child health Millennium Development Goals.
Norheim, Ole F, Ngalesoni Frida N, Ruhago, George M., Norheim Ole F, Ruhago George M, Hulme, David; id_orcid, Ole F Norheim, Ngalesoni, F.N., Norheim, Ole Frithjof, Norheim, O.F., Wilkinson, Rorden, Ngalesoni, Frida N., Ruhago, G.M., Norheim, Ole F., Ngalesoni, Frida N, Ngalesoni, Frida, George M Ruhago, Ruhago, George M, Frida N Ngalesoni   +18 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source