Results 41 to 50 of about 136,134 (263)

The provision and utilization of essential health services in Afghanistan during COVID-19 pandemic

Frontiers in Public Health, 2023
IntroductionThe COVID-19 pandemic has disrupted provision of essential health services and overwhelmed even robust health systems worldwide. The Afghanistan health system has suffered both from the pandemic, as well as from political upheaval and regime ...
Narges Neyazi, Christina Lindan, Saber Perdes, Abdul Ghani Ibrahimi, Dirk Horemans, Deena Al Afsoor   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Greater political commitment needed to eliminate malaria

Infectious Diseases of Poverty, 2019
Malaria-related mortality has a very high association with poverty rates, and the disease is most prevalent in low- and middle-income countries. To achieve the malaria-specific targets of the Sustainable Development Goals, malaria-endemic countries and ...
Minghui Ren
doaj   +1 more source

Evaluation of the implementation of hospital hygiene components in 30 health-care facilities in the autonomous district of Abidjan (Cote d’Ivoire) with the WHO Infection Prevention and Control Assessment Framework (IPCAF)

BMC Health Services Research, 2023
Introduction As part of the implementation of its mission “to integrate hygiene activities into healthcare”, the general directorate of health conducted in 2018 with its technical structures, an evaluation of the implementation of Infection Prevention ...
Doumbia Mariamou Cissé, Essis Esme Marie Laure, Koné Atioumounan Blaise, N’gbesso N’gbesso Jean Paul, Mbengue Valérie Gbonon, Cissé Raïssa Adja Mayaka, Gagne Doh Eugénie, Dagnan N’cho Simplice, Kouadio Luc Philippe, Samba Mamadou   +9 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The cost of health workforce gaps and inequitable distribution in the Ghana Health Service: an analysis towards evidence-based health workforce planning and management

Human Resources for Health, 2021
Background Despite tremendous health workforce efforts which have resulted in increases in the density of physicians, nurses and midwives from 1.07 per 1000 population in 2005 to 2.65 per 1000 population in 2017, Ghana continues to face shortages of ...
James Avoka Asamani, Hamza Ismaila, Anna Plange, Victor Francis Ekey, Abdul-Majeed Ahmed, Margaret Chebere, John Koku Awoonor-Williams, Juliet Nabyonga-Orem   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Capacity and service readiness of facilities for non-communicable diseases in Bangladesh: a health system perspective from two selected districts

BMC Health Services Research
Background Non-communicable diseases (NCDs) are a growing health crisis in Bangladesh and a leading cause of morbidity and mortality. This study assessed the capacity and service readiness of healthcare facilities for the management of NCDs, including ...
Masudur Rahman Kanchon, Md. Rakib Akon, Zarin Tasnim, Nahitun Naher, Lamisa Rahman, Nicole Fraser-Hurt, Syed Masud Ahmed   +6 more
doaj   +1 more source

Gearing health systems for universal health coverage

Frontiers in Health Services, 2023
Universal health coverage requires adequate and sustainable resourcing, which includes human capital, finance and infrastructure for its realization and sustainability. Well-functioning health systems enable health service delivery and therefore need to be either adequately or optimally geared—prepared and equipped—for service delivery to advance ...
Marlon E. Cerf, Marlon E. Cerf
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source