Results 51 to 60 of about 136,134 (263)

Achieving universal health coverage

Bulletin of the World Health Organization, 2015
There is global consensus on the goals of universal health coverage (UHC), which has been defined as “all people receiving quality health services that meet their needs without exposing them to financial hardship in paying for them.”1 Yet despite this consensus, it remains unclear how the global health community can achieve universal coverage.
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Improving quality of care for maternal and newborn health: a pre-post evaluation of the Safe Childbirth Checklist at a hospital in Bangladesh

BMC Pregnancy and Childbirth, 2017
Background Bangladesh has achieved major gains in maternal and newborn survival, facility childbirth and skilled birth attendance between 1991 and 2010, but excess maternal mortality persists.
Herfina Y. Nababan, Rubana Islam, Shabnam Mostari, Md Tariqujjaman, Malabika Sarker, Mohammad Tajul Islam, Corrina Moucheraud   +6 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Optimizing the roles of health workers to improve access to health services in Africa: an implementation framework for task shifting and sharing for policy and practice

BMC Health Services Research, 2023
Background Globally, countries are taking actions to ensure that their population have improved access to people-centred and integrated health services.
Sunny C Okoroafor, Christmal Dela Christmals   +1 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Developing a Trauma System Improvement Program (TSIP) in Bangladesh: findings from a pilot study

BMC Emergency Medicine
Introduction The Trauma System Improvement Program (TSIP) plays a crucial role in improving trauma care outcomes. Despite its importance, the development and implementation of a hospital-based TSIP for road traffic injury (RTI) victims has received ...
Zarin Tasnim, Md Karimuzzaman, Nahitun Naher, Bushra Zarin Islam, Samiun Nazrin Bente Kamal Tune, Amber Mehmood, Suresh Kunhi Mohammed, S. M. Asib Nasim, Rafi Hossain, Syed Masud Ahmed   +9 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Knowledge, attitudes, and practices on antibiotic use and resistance among adolescents and young people in Sierra Leone: a cross-sectional study

BMC Public Health
Background The studies on knowledge, attitudes, and practices of Antimicrobial resistance (AMR) and use among adolescents and young people are largely from Europe and the Asia region.
Ibrahim Franklyn Kamara, Sia Morenike Tengbe, Patricia Abu, Binyam Hailu, Tumisang Malebo Madisa, Bobson Derrick Fofanah, Fatmata Bintu Kargbo, Bintu Mansaray, Pruthu Thekkur, Mariama Mustapha, Massimo Sartelli, Yahaya Ali Ahmed, George Ameh   +12 more
doaj   +1 more source