Results 61 to 70 of about 1,241,739 (286)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Investigation into contemplating the Self in a spiritual and transpersonal psychological context
Theologia Viatorum, 2016 This article is intended as an original contribution towards contemplation of the Self with special reference to a spiritual and transpersonal psychological context.
S. D. Edwards +3 more
doaj +1 more source
Revista Panamericana de Salud Pública, 2020 El desafío de avanzar hacia la materialización del derecho a la salud para todos a través de la estrategia para el acceso y la cobertura universal de salud (salud universal) requiere de múltiples condiciones y acciones.
Osvaldo Artaza +7 more
doaj +1 more source
Morse-Novikov critical point theory, Cohn localization and Dirichlet units
, 1999 In this paper we construct a Universal chain complex, counting zeros of closed 1-forms on a manifold. The Universal complex is a refinement of the well known Novikov complex; it relates the homotopy type of the manifold, after a suitable noncommutative ...
Farber, M.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Universal Hitting Time Statistics for Integrable Flows [PDF]
Journal of Statistical Physics, 2016 The perceived randomness in the time evolution of "chaotic" dynamical systems can be characterized by universal probabilistic limit laws, which do not depend on the fine features of the individual system. One important example is the Poisson law for the times at which a particle with random initial data hits a small set.
Carl P. Dettmann +2 more
openaire +7 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Hacia el aseguramiento universal en salud en el Perú
Revista Peruana de Medicina Experimental y Salud Pública, 2009 Recientemente se ha aprobado la Ley Marco de Aseguramiento Universal en Salud, sin embargo, la denominación de esta Ley excede largamente su contenido pues no remarca una mejora significativa en la protección social y financiera en salud para todos los ...
Julio Castro
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Declaração Universal dos Direitos Humanos
Comunicação & Educação, 1995 Reprodução integral da Declaração Universal dos Direitos do Homem, adotada e proclamada a 10 de dezembro de 1948 pela Assembléia Geral das Nações Unidas.
ONU - Organização das Nações Unidas
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