Results 51 to 60 of about 589,865 (307)

A Critical Dialogue on the Cosmopolitan Turn in Communication Studies

open access: yesGlobal Media Journal: German Edition
This discussion engages with the collective volume Cosmopolitan Communication Studies: Toward Deep Internationalization. The editors and contributors call for a cosmopolitan reorientation of communication studies that transcends enduring Eurocentric ...
Anke Fiedler   +5 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

What’s D&T for? Gathering and comparing the values of design and technology academics and trainee teachers

open access: yes, 2015
Some who read and research about Design & Technology (D&T) would say that the concept of value is key to understanding and defining D&T. Closer inspection reveals though that there are two ways in which values are defined in D&T: how values are taught ...
Hardy, Alison, Hardy, A
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

“But it sometimes happens that something is not and is, and is more real than it would be”. Concepts of hope in “Drzewo” by Wiesław Myśliwski

open access: yesStudia Humanitatis, 2017
“Drzewo” (“The Tree”) – a play by Wiesław Myśliwski, the outstanding Polish contemporary writer – is one of his four dramas (apart from “Złodziej”, 1973; “Klucznik”, 1978 and “Requiem dla gospodyni”, 2000).
Jarosz Agnieszka
doaj  

An Overview of the Schwartz Theory of Basic Values

open access: yes, 2012
This article presents an overview of the Schwartz theory of basic human values. It discusses the nature of values and spells out the features that are common to all values and what distinguishes one value from another.
Shalom H. Schwartz, Schwartz, Shalom H.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Values Following a Major Terrorist Incident: Finnish Adolescent and Student Values Before and After September 11, 2001

open access: yes, 2006
The horrific terrorist attacks on the United States on September 11, 2001, left an indelible mark on perceptions of security and threat across the world.
Goodwin, R   +5 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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