Results 71 to 80 of about 589,865 (307)
Universal Value-Function Uncertainties
CoRREstimating epistemic uncertainty in value functions is a crucial challenge for many aspects of reinforcement learning (RL), including efficient exploration, safe decision-making, and offline RL. While deep ensembles provide a robust method for quantifying value uncertainty, they come with significant computational overhead.
Moritz A. Zanger +6 more
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
On the structure of the boolean-valued universe
Владикавказский математический журнал, 2018 Уточнен логический механизм, стоящий за объявлением гипотез. В том числе, уделено внимание гипотезам и заключениям, представляющим собой бесконечные наборы формул. Приведены формальные определения булевозначной алгебраической системы и модели теории, определение системы термов булевозначной оценки истинности формул, подъема и перемешивания.
openaire +2 more sources
PEDAGOGICAL VALUES. EDUCATION AS A UNIVERSAL VALUE
, 2023 In this article, the concept of pedagogical value, its content, scope of application. Factors determining the essence of value, the role and importance of values in pedagogical professional activity are discussed.
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Making Students Aware of the Universal Human Values
ACROSS, 2021 This increases the importance of higher education as a factor of socialization of students, as well as the role of the university educational process in the personal and professional development and especially that of the future teacher of the younger ...
Nadiia KICHUK, Antonina KICHUK
doaj
Tendering Universal Service Obligations in Liberalized Network Industries [PDF]
In the past decades, several countries have introduced reverse auctions for allocating universal service or public mission subsidies in various industries. Examples include urban transport, air transport and telecommunications.
Christian Jaag, Urs Trinkner
core
Harmonization of Education and Social Development with Universal Values in Jadidism
, 2023 This article examines the doctrine of Jadidism, a cultural and educational movement that emerged in Central Asia during the late 19th and early 20th centuries.
Sevara Asanbaevna Kurbanova
core