Results 81 to 90 of about 589,865 (307)

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 [PDF]

open access: yes, 2020
Background: Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship.
Lalloo, Ratilal   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Fostering values in organizations [PDF]

open access: yes
Today, values hold a prominent place both in business ethics and in organization theory. However, there persists considerable confusion about what these values are and what role they play in these theories and, therefore, how they can be developed both ...
Argandoña, Antonio
core  

REFLECTION OF COMPOUND WORDS IN ENGLISH AND UZBEK LANGUAGES IN NATIONAL VALUES

open access: yes, 2023
Language and culture are closely intertwined and shaped by each other. Compound words of a language, are not only an important part of a language but also a “window” through which one can observe national and cultural facets of a nation.
Ergashevna, Yusupova Sevara
core  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

From Values to Religion

open access: yesRIMCIS, 2012
Each individual is guided by values that determine his behaviour. A recurrent distinction concerns the difference between applied values and final values, therefore between values concerning individual practices and values which represent real goals to ...
Roberto Cipriani
doaj   +1 more source

What is the University for: Balancing Instrumental Value with Other Forms of Value in the Contemporary University

open access: yesPhilosophy and Theory in Higher Education
Abstract In this paper, we ask what is the university for? Currently, universities worldwide are facing a legitimacy crisis, contesting and threatening what the purpose of the university is. Higher education institutions are under pressure to serve economical goals both nationally and globally, hindering a more robust sense of purpose.
Shumar , Wesley   +2 more
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

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