Results 31 to 40 of about 1,966 (263)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
El estatuto ontológico de las categorías
Pensamiento. Revista de Investigación e Información Filosófica, 2016 Este artículo constituye una investigación sobre el estatuto ontológico de las categorías. Examina cuatro tesis: (a) que las categorías son lingüísticas, (b) que son meramente lógicas, (c) que son reales todas y (d) que algunas son reales y otras lógicas
Carlos A. Casanova
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Leyes y hacedores de verdad: una interpretación crítica del realismo nomológico de M. Tooley
Filosofia Unisinos, 2015 La tesis principal defendida por Michael Tooley en su artículo The Nature of Laws sostiene que son las relaciones entre universales los auténticos hacedores de verdad de los enunciados nomológicos y de las leyes.
Susana Mafalda Lucero, Roberto Azar
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Adhesivos universales en restauraciones directas [PDF]
Revista Científica Universidad Odontológica DominicanaIntroducción: Para evaluar la fuerza adhesiva se debe evaluar los siguientes parámetros: Fuerza de unión, resistencia de micro-tensión, resistencia de cizallamiento o cizalladura.
Arianna Macías Chiliquinga +1 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Nuevo Trabajo para una Teoría de los Universales
Ideas y Valores, 2015 Nota del traductor: El texto que se presenta aquí es la primera parte de la traducción,correspondiente a la introducción y las dos primeras secciones del artículo original.
David Lewis, Diego Morales (trad.)
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