Results 41 to 50 of about 1,966 (263)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
El escepticismo de la asimetría y la teoría de la referencia de Strawson
Ideas y Valores, 2003 El propósito de este artículo es presentar el debate sobre la distinción entre universales y particulares en la filosofía analítica. En el texto se examinan las objeciones de Ramsey a los intentos de trazar la distinción y los argumentos de Strawson para
Mauricio Rengifo
doaj
ECUACIONES PARA CONTROLADORES PID UNIVERSALES
Ingeniería, 2011 Se propone la utilización de solamente dos ecuaciones para representar a los controladores PID. El controlador PID Universal tipo Paralelo (PIDup) y el controlador PID Universal tipo Serie (PIDus), junto con un conjunto único de parámetros que permiten ...
Víctor M. Alfaro Ruíz
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
CríticaVarios filósofos han propuesto un enfoque “algebraico” de los universales de acuerdo con el cual hay operaciones de universales a universales. No es obvio, sin embargo, cómo estas operaciones deban ser interpretadas y qué impacto tengan para las ...
José Tomás Alvarado Marambio
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Koers - Bulletin for Christian Scholarship, 1964 Die posisie van Studium Universale (as interdissiplinêre kursus) aan die Potchefstroomse Universiteit vir Christelike Hoër Onderwys is in sekere opsigte uniek in die Westerse universitêre wêreld. In ander opsigte is dit analoog met derge- like kursusse aan Europese en Amerikaanse universiteite.
openaire +3 more sources
Crisis de las comunidades, crisis de los universales
Revista Chuy, 2019 Intervención de apertura de la Jornada "Totalidades quebradas. Lecturas de pasado y presente" organizadas por el PELCC en el Ateneu Candela (Terrassa, Barcelona: jueves 29 de septiembre de 2016), en el marco del proyecto internacional “Narrativas ...
Daniel Link
doaj