Results 61 to 70 of about 1,966 (263)

Nominalismo, conceptualismo y realismo en la teoría estoica de los universales

Crítica, 2018
El objetivo de este trabajo es, por una parte, ofrecer una nueva interpretación de la teoría estoica de los universales a la luz del debate entre nominalismo, conceptualismo y realismo, y, por otra, desentrañar un paralelismo entre el análisis propuesto
Ricardo Salles
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

NOMIANLISMOS DE PROPIEDADES

Daimon
En el presente artículo se exponen las diferentes teorías de las propiedades realizadas desde el nominalismo estricto y apuntamos los problemas fundamentales de las mismas.
Joan Pagès
doaj  

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Universale Durchflussströmungsmesser [PDF]

CITplus, 2019
Aufgrund der umfangreichen Möglichkeiten zur Vor‐Ort‐Programmierung eignen sich die Durchflussregler MIM und MIS von KOBOLD Messring für einen branchenübergreifenden Einsatz insbesondere bei der Dosierung.
openaire   +1 more source

Enfoque híbrido simulación-proceso analítico jerárquico: caso de estudio del rediseño de un restaurante || Hybrid Approach between Analytic Hierarchy Process and Simulation: Case Study, Redesign of a Restaurant

Revista de Métodos Cuantitativos para la Economía y la Empresa, 2014
La simulación ha demostrado ser una técnica potente y particularmente eficaz para valorar diferentes alternativas de solución de problemas, sin ser necesaria su experimentación real.
González Sánchez, Caridad, Garza Ríos, Rosario, Pérez Malo, Eduardo   +2 more
doaj  

Universales del lenguaje. Una consideración semántica

Lenguaje, 1973
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Hector Ríos M.
doaj   +1 more source

[The importance of a gender focus in building resilient, equitable, and universal health systemsA importância da abordagem de gênero no desenvolvimento de sistemas de saúde resilientes, equitativos e universais]. [PDF]

Rev Panam Salud Publica, 2023
Fitzgerald J, Schutt-Aine J, Houghton N, De Bortoli Cassiani SH, Báscolo E, Alarcón G, Nascimento Sena AG.   +6 more
europepmc   +1 more source