Results 71 to 80 of about 220,085 (291)
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Crisis de las comunidades, crisis de los universales
Revista Chuy, 2019 Intervención de apertura de la Jornada "Totalidades quebradas. Lecturas de pasado y presente" organizadas por el PELCC en el Ateneu Candela (Terrassa, Barcelona: jueves 29 de septiembre de 2016), en el marco del proyecto internacional “Narrativas ...
Daniel Link
doaj
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
La singularidad ¿por qué no puede ser abordada por la Ciencia? [PDF]
, 2010 Lo singular, conjuntamente con lo universal y lo particular ha sido un atributo lógico de un tipo de juicios clasificados según su cantidad.
Lizarraga, Carolina, Minhot, Leticia
core
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Los universales como ficciones (figmenta) según Juan de Salisbury
Patristica et Mediaevalia, 2012 En el presente artículo analizamos Metalogicon, II, 20 de Juan de Salisbury en vistas de identificar su dependencia de las consideraciones de Boecio respecto a la obtención de los conceptos universales.
Antonio Tursi
doaj
Differenz, 2017 La existencia de esencias universales ha sido una constante problemática a lo largo de la historia de la metafísica occidental. Reconocemos su necesidad epistemológica, pero dudamos acerca de su verdad metafísica. Ahora bien, es posible que el origen del
Miguel Ángel Bueno Espinosa
doaj +1 more source
Von der Arithmetik zur Algebra [PDF]
, 2012 Arithmetik ist mehr als das Berechnen von Termwerten, Algebra ist mehr als das Umformen von Termen: Bereits in der Arithmetik kann das inhaltliche Verständnis für Algebra geweckt werden.
Marxer, Michael
core
Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt +5 more
wiley +1 more source