Results 131 to 140 of about 1,114,161 (348)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
When Hell is Other People. Interiority and Skepticism in António Lopes da Veiga
Culture & History Digital Journal, 2017 The study of the process of construction of modern subjectivity offers an image of constant tensions between universality and particularity, which could be considered a manifestation of the conflictual nature of Modernity itself.
Fernando Rodríguez Mediano +1 more
doaj +1 more source
On the Renormalization Group Explanation of Universality [PDF]
, 2016 It is commonly claimed, both by physicists and philosophers that the universality of critical phenomena is explained through particular applications of the Renormalisation Group (RG).
Franklin, Alexander +2 more
core +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
A Mixed Joint Universality Theorem for Zeta-Functions. II
Mathematical Modelling and Analysis, 2014 In the paper, a joint universality theorem on the approximation of analytic functions for zeta-function of a normalized Hecke eigen cusp form and a collection of periodic Hurwitz zeta-functions with algebraically independent parameters is obtained.
Vaida Pocevičienė +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Universality and Generality in Ethical Norms [PDF]
, 2014 Harrod regards classical utilitarianism, represented by Bentham, as crude\ utilitarianism. However, he refers to his own utilitarianism as refined utilitarianism.
田中, 朋弘 +2 more
core +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source