Results 51 to 60 of about 1,105,380 (358)
Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack +12 more
wiley +1 more source
Dostoevsky in English and Shakespearean Universality: A Cautionary Tale
Multicultural Shakespeare, 2020 This is the second of a pair of articles addressing the relationship between Dostoevsky’s novella Notes from the Underground and Shakespeare’s Hamlet.
Chris Thurman
doaj +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Reinventing the Self: A Philosophical Encounter with the Historiography of Cultural Identity [PDF]
تاریخ نگری و تاریخ نگاری, 2019 In addressing identity, many commentators have primarily focused on three types of associations: by land (shared history, geography, state); by blood (shared ethnicity, race); and/or by culture (shared language, religion, arts, and sciences).
Hossein Mesbahian
doaj +1 more source
, 2022 La red “UNIVERSITY of Universities” no cesa de amoldarse a los continuos cambios de las circunstancias docentes, económicas, de conflictos internacionales y por supuesto de pandemia. Lo importante es entender cada restricción como una oportunidad de proyecto.
Sánchez Merina, Francisco Javier +4 more
openaire +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
The TPNW Conference of Parties: What Is to Be Discussed?
Journal for Peace and Nuclear Disarmament, 2020 The Treaty on the Prohibition of Nuclear Weapons (TPNW) is one of the most important developments of the modern era. This paper addresses the question posed, of what issues are to be discussed at the 1st Conference of the States Parties to the Treaty ...
Kennedy Graham
doaj +1 more source
Human Rights beyond Dichotomy between Cultural Universalism and Relativism
Age of Human Rights Journal, 2020 The consolidation of relations of global society requires the progressive establishment of a global legal system, consisting of a system of rules - precisely, human rights - as the source and evaluation criteria of positive national rights.
Edna Raquel Hogemann
doaj +1 more source
Universality Reconsidered: Diversity in Making Meaning of Facial Expressions
Current Directions in Psychological Science, 2018 It has long been claimed that certain facial movements are universally perceived as emotional expressions. The critical tests of this universality thesis were conducted between 1969 and 1975 in small-scale societies in the Pacific using confirmation ...
M. Gendron +2 more
semanticscholar +1 more source
Revisiting Lepton Flavor Universality in B Decays. [PDF]
Physical Review Letters, 2016 Lepton flavor universality (LFU) in B decays is revisited by considering a class of semileptonic operators defined at a scale Λ above the electroweak scale v. The importance of quantum effects, so far neglected in the literature, is emphasized.
F. Feruglio, P. Paradisi, Andrea Pattori
semanticscholar +1 more source