Results 61 to 70 of about 122,094 (297)
Non-Trivial Universes and Sequences of Universes
Formalized Mathematics, 2022 Summary Universe is a concept which is present from the beginning of the creation of the Mizar Mathematical Library (MML) in several forms (Universe, Universe_closure, UNIVERSE) [25], then later as the_universe_of, [33], and recently with the definition GrothendieckUniverse [26], [11], [11].
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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AxiomsThe famous Riemann hypothesis (RH) asserts that all non-trivial zeros of the Riemann zeta function ζ(s) (zeros different from s=−2m, m∈N) lie on the critical line σ=1/2.
Antanas Laurinčikas
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Computational universality in symbolic dynamical systems
, 2004 Many different definitions of computational universality for various types of systems have flourished since Turing’s work. In this paper, we propose a general definition of universality that applies to arbitrary discrete time symbolic dynamical systems ...
n/a +8 more
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Universality versus variation in the conceptualization of anger: A question of methodology
Russian Journal of LinguisticsCognitive linguistic investigations into the metaphorical conceptualization of anger suggest that languages are remarkably similar on a schematic level, with intensity and control as two, possibly universal dimensions underlying the metaphorical ...
Zoltán Kövecses +3 more
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
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