Results 61 to 70 of about 952,940 (263)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Dostoevsky in English and Shakespearean Universality: A Cautionary Tale
Multicultural Shakespeare, 2020 This is the second of a pair of articles addressing the relationship between Dostoevsky’s novella Notes from the Underground and Shakespeare’s Hamlet.
Chris Thurman
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Fixed energy universality of Dyson Brownian motion [PDF]
Advances in Mathematics, 2016 We consider Dyson Brownian motion for classical values of $\beta$ with deterministic initial data $V$. We prove that the local eigenvalue statistics coincide with the GOE/GUE in the fixed energy sense after time $t \gtrsim 1/N$ if the density of states ...
B. Landon, Philippe Sosoe, H. Yau
semanticscholar +1 more source
Reinventing the Self: A Philosophical Encounter with the Historiography of Cultural Identity [PDF]
تاریخ نگری و تاریخ نگاری, 2019 In addressing identity, many commentators have primarily focused on three types of associations: by land (shared history, geography, state); by blood (shared ethnicity, race); and/or by culture (shared language, religion, arts, and sciences).
Hossein Mesbahian
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The TPNW Conference of Parties: What Is to Be Discussed?
Journal for Peace and Nuclear Disarmament, 2020 The Treaty on the Prohibition of Nuclear Weapons (TPNW) is one of the most important developments of the modern era. This paper addresses the question posed, of what issues are to be discussed at the 1st Conference of the States Parties to the Treaty ...
Kennedy Graham
doaj +1 more source
Human Rights beyond Dichotomy between Cultural Universalism and Relativism
Age of Human Rights Journal, 2020 The consolidation of relations of global society requires the progressive establishment of a global legal system, consisting of a system of rules - precisely, human rights - as the source and evaluation criteria of positive national rights.
Edna Raquel Hogemann
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Universality and diversity in human song
, 2018 What is universal about music across human societies, and what varies? We built a corpus of ethnographic text on musical behavior from a representative sample of the world’s societies and a discography of audio recordings of the music itself.
Samuel A. Mehr +18 more
semanticscholar +1 more source