Results 51 to 60 of about 122,094 (297)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The TPNW Conference of Parties: What Is to Be Discussed?
Journal for Peace and Nuclear Disarmament, 2020 The Treaty on the Prohibition of Nuclear Weapons (TPNW) is one of the most important developments of the modern era. This paper addresses the question posed, of what issues are to be discussed at the 1st Conference of the States Parties to the Treaty ...
Kennedy Graham
doaj +1 more source
Moral category of human rights in the country’s defense [PDF]
Војно дело, 2016 Nowadays the world is defined and essentially functions through the idea of law and justice. Human rights are among basic values of modern civilization and are becoming a matter of general concern and international responsibility.
Narančić Mane
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Music: Specialized to Integrate?
Empirical Musicology Review, 2015 In her paper Schaefer (2014) provides a relevant amount of behavioral and neuroimaging evidence within and outside the realm of music favoring the notion that predictive processing plays a prominent role in the coupling of perception, cognition and ...
Paulo Estêvão Andrade +1 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Simultaneous universality [PDF]
, 2018 In this paper, the notion of simultaneous universality is introduced, concerning operators having orbits that simultaneously approximate any given vector.
Bernal González, Luis +3 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Critical remarks on Religion in the public sphere' – Habermas between Kant and Kierkegaard
Etikk i Praksis: Nordic Journal of Applied Ethics, 2009 This article provides a critical assessment of Habermas's recent work on religion and the role of religion in the public sphere by comparing it to Kant's philosophy of religion on the one hand and that of Kierkegaard on the other.
Roe Fremstedal
doaj +1 more source