Results 81 to 90 of about 122,094 (297)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Connecting Glass-Forming Fragility to Network Topology
Frontiers in Materials, 2019 Glass fragility is a byproduct of early attempts to apply law of corresponding states scaling to the temperature dependent thickening of glass forming liquids. Efforts to plot the logarithm of the viscosity vs.
David L. Sidebottom
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Upper bounds for the density of universality. II [PDF]
, 2005 summary:We prove explicit upper bounds for the density of universality for Dirichlet series. This complements previous results [15]. Further, we discuss the same topic in the context of discrete universality.
Steuding, Jörn
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The Struggle over Airways in the Americas, 1919-1945 [PDF]
, 2006 This chapter appeared in Intimate Universality: Local and Global Themes in the History of Weather and Climate ...
Cushman, Gregory T.
core +1 more source
ARE HUMAN RIGHTS OF RELIGIOUS ORIGIN?
Sur: International Journal on Human Rights, 2019 Are human rights codified in the late eighteenth century by natural rights of divine or philosophical origin? This question haunted Western political thought throughout the nineteenth and twentieth centuries.
Valentine Zuber
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2017 This paper deals with the problem of universality property of logic. At first, this property is analyzed in the context of first-order logic. Three senses of the universality property are distinguished: universal applicability, topical neutrality and ...
Jan Woleński, Woleński, Jan
core +2 more sources