Results 81 to 90 of about 1,075,998 (360)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal +8 morewiley +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourceIntein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more sourceTest of lepton universality using b+ → K+ℓ+ℓ- decays.
Physical Review Letters, 2014 A measurement of the ratio of the branching fractions of the B(+) → K(+)μ(+)μ(-) and B(+) → K(+)e(+)e(-) decays is presented using proton-proton collision data, corresponding to an integrated luminosity of 3.0 fb(-1), recorded with the LHCb experiment at R. Aaij, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, S. Akar, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A. A. Alves, S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J. Andrews, R. Appleby, O. Aquines Gutiérrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J. Back, A. Badalov, V. Balagura, W. Baldini, R. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, V. Battista, A. Bay, L. Beaucourt, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M. Bettler, M. van Beuzekom, A. Bieñ, S. Bifani, T. Bird, A. Bizzeti, P. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. V. D. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, J. Brodzicka, N. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, M. Calvi, M. Calvo Gómez, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo García, M. Cattaneo, C. Cauet, R. Cenci, M. Charles, P. Charpentier, S. Chen, S. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P. Clarke, M. Clemencic, H. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G. Cowan, D. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D’Ambrosio, J. Dalseno, P. David, P. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, K. Dreimanis, G. Dujany, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, C. Elsasser, S. Ely, S. Esen, H. Evans, T. Evans, A. Falabella, C. Färber, C. Farinelli, N. Farley, S. Farry, R. Fay, D. Ferguson, V. Fernández Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. García Pardiñas, J. Garofoli, J. Garra Ticó, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, G. Gavrilov, E. Gersabeck, M. Gersabeck, T. Gershon, P. Ghez, A. Gianelle, S. Gianì, V. Gibson, L. Giubega, V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, H. Gordon, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L. Granado Cardoso, E. Grauges, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Y. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S. Harnew, J. Harrison, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, P. H. Hopchev, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, F. Jing, M. John, D. Johnson, C. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T. M. Karbach, S. Karodia, M. Kelsey, I. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, K. Klimaszewski, O. Kochebina, M. Kolpin, I. Komarov, R. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R. Lambert, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J. Lees, R. Lefèvre, A. Leflat, J. Lefrancois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, G. Liu, S. Lohn, I. Longstaff, J. Lopes, N. López-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, G. Manca, G. Mancinelli, J. Maratas, J. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. M. Martín Sánchez, M. Martinelli, D. Martínez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Máthé, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D. Milanes, M. Minard, N. Moggi, J. Molina Rodriguez, S. Monteil, M. Morandin, P. Morawski, A. Mordà, M. Morello, J. Moroń, A. Morris, R. Mountain, F. Muheim, K. Müller, M. Mussini, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A. Nguyen, T. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, D. O’Hanlon, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J. Otalora Goicochea, P. Owen, A. Oyanguren, B. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, C. Parkes, C. Parkinson, G. Passaleva, G. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, E. Price, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J. Rademacker +499 moresemanticscholar +1 more sourceA guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
Molecular Oncology, EarlyView.Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond +3 morewiley +1 more sourceUniversality of Human Microbial Dynamics
Nature, 2016 A new computational method to characterize the dynamics of human-associated microbial communities is applied to data from two large-scale metagenomic studies, and suggests that gut and mouth microbiomes of healthy individuals are subjected to universal ...A. Bashan, T. Gibson, Jonathan Friedman, V. Carey, S. Weiss, E. Hohmann, Yang-Yu Liu +6 moresemanticscholar +1 more source
