Results 81 to 90 of about 1,105,380 (358)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Two Universality Properties Associated with the Monkey Model of Zipf’s Law
Entropy, 2016 The distribution of word probabilities in the monkey model of Zipf’s law is associated with two universality properties: (1) the exponent in the approximate power law approaches −1 ...
Richard Perline, Ron Perline
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Reading Provincializing Europe as a Missed Opportunity
Práticas da História, 2020 This essay explores Chakrabarty’s introduction of the expression “provincializing Europe” as a privileged way of understanding history in modern conditions.
Réal Fillion
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Connecting Glass-Forming Fragility to Network Topology
Frontiers in Materials, 2019 Glass fragility is a byproduct of early attempts to apply law of corresponding states scaling to the temperature dependent thickening of glass forming liquids. Efforts to plot the logarithm of the viscosity vs.
David L. Sidebottom
doaj +1 more source
Effective of Educational Instruction of Nurses Knowledge Regarding Meningitis and Universal Precaution Measures at Selected Department at Minia Fever Hospital [PDF]
, 2021 Nemaat A. Hussien +3 more
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source