Results 81 to 90 of about 419,064 (295)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Interacting Monomer-Dimer Model with Infinitely Many Absorbing States
, 1998 We study a modified version of the interacting monomer-dimer (IMD) model that has infinitely many absorbing (IMA) states. Unlike all other previously studied models with IMA states, the absorbing states can be divided into two equivalent groups which are
G. Grinstein +25 more
core +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Reading Provincializing Europe as a Missed Opportunity
Práticas da História, 2020 This essay explores Chakrabarty’s introduction of the expression “provincializing Europe” as a privileged way of understanding history in modern conditions.
Réal Fillion
doaj +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Connecting Glass-Forming Fragility to Network Topology
Frontiers in Materials, 2019 Glass fragility is a byproduct of early attempts to apply law of corresponding states scaling to the temperature dependent thickening of glass forming liquids. Efforts to plot the logarithm of the viscosity vs.
David L. Sidebottom
doaj +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
How to discriminate easily between Directed-percolation and Manna scaling
, 2007 Here we compare critical properties of systems in the directed-percolation (DP) universality class with those of absorbing-state phase transitions occurring in the presence of a non-diffusive conserved field, i.e.
Bonachela, Juan A., Munoz, Miguel A.
core +2 more sources
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
ARE HUMAN RIGHTS OF RELIGIOUS ORIGIN?
Sur: International Journal on Human Rights, 2019 Are human rights codified in the late eighteenth century by natural rights of divine or philosophical origin? This question haunted Western political thought throughout the nineteenth and twentieth centuries.
Valentine Zuber
doaj