Results 141 to 150 of about 113,830 (296)

ANTİK ÇAĞDA ZORUNLU VARLIK ANLAYIŞININ ÖNCÜSÜ PARMENİDES

open access: yesFelsefe Dünyası, 2016
Aklı dolayısıyla düşünme ve bilgi elde etme gücüne sahip olan insan, deney ve gözlemleri sonucunda elde ettiği bulguları değerlendirerek kendisinin asla şüphe etmeyeceği kesin bilgilere ulaşmasıyla evrenin seçkin varlığı olma vasfını elinde bulundurmakla
Mehmet Akgün
doaj  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Universal healthcare but not universal access? [PDF]

open access: yesEuropean Journal of Preventive Cardiology, 2019
Jasper Tromp, Sean P. Collins
openaire   +2 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

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