Results 61 to 70 of about 119,582 (299)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

ChemMaps.com v2.0: exploring the environmental chemical universe [PDF]

open access: gold, 2023
Alexandre Borrel   +5 more
openalex   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

AŞKIN (SEVGİNİN) GÜCÜ

open access: yesFelsefe Dünyası, 2005
Ömer ÖZDEN, AŞKIN (SEVGİNİN) GÜCÜ, FELSEFE DÜNYASI DERGİSİ, SAYI:42 ...
Ömer Özden
doaj  

The Problem of Unity and Plurality in Teftâzânî

open access: yesDin ve Bilim Muş Alparslan Üniversitesi İslami İlimler Fakültesi Dergisi
In the religious texts of Muslims, some commands praise all forms of wisdom and emphasize the necessity of acquiring wisdom wherever it is found. For this reason, from the early periods, the Islamic intellectual movement made great efforts to become ...
Ekrem UĞURLU
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

İnsanın Yabancılaşmasına Yönelik Sȗfȋ Perspektif / Sufi Perspective of Human Alienation / اغتراب الإنسان من خلال المنظور الصوفي

open access: yesİlahiyat Akademi, 2016
En büyük kriz insanlık krizidir. Ekonomik, sosyal, siyasal ve kültürel krizler belki bir şekilde aşılabilir ama insanlık krizi tamiri kolay olmayan büyük yaralar açar. O nedenle en büyük yatırım insana yapılan yatırımdır.
Kadir Özköse
doaj  

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

První koncepce kulovité Země v antické kosmologii

open access: yesFilosofický časopis, 2022
Although it is not until we get to Aristotle that we can be absolutely certain of finding a spherical Earth in ancient cosmology, Diogenes Laertios considers it to have been first conceived by Pythagoras and Parmenides.
Kočandrle, Radim
doaj   +1 more source

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