Results 81 to 90 of about 119,582 (299)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Efforts to Save the Universe: Muhammadiyah's Concern for the Environment
SuhufMuhammadiyah as a part of the civilization has a responsibility to spread the mercy. The organization that founded by KH Ahmad Dahlan is not carrying the theme "Efforts to Save the Universe" for its 111th anniversary in 2023 without reason.
Shubhi Mahmashony Harimurti +1 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Universal Grammar is a universal grammar
, 2014 Language is the most distinctive feature of humans, but there is no consensus on what is characteristic of language. From the point of view of computing, we argue that ‘the human brain circuitry that implements language is Turing complete’. This thesis makes evolutionary sense and natural languages are expressive enough, but two issues against it ...
openaire +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Probing the pre-BBN universe with gravitational waves from cosmic strings [PDF]
, 2019 Yanou Cui +3 more
openalex +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Neutrinos help reconcile Planck measurements with both the early and local Universe [PDF]
, 2014 Cora Dvorkin +3 more
openalex +1 more source
International Journal of Modern Physics D, 2004 Cosmology, high-energy physics and astrophysics are today converging to the study of large scale magnetic fields. While the experimental evidence for the existence of large scale magnetization in galaxies, clusters and super-clusters is rather compelling, the origin of the phenomenon remains puzzling especially in light of the most recent observations.
openaire +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source