Results 201 to 210 of about 1,298,736 (355)
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Multiculturalismo, interculturalidad y liderazgo [PDF]
, 2008 En el contexto de la globalización, la universidad no se mide exclusivamente en relación con su propio cometido o con otras universidades del país o de la región; una universidad se mide inevitablemente en relación con las universidades más competitivas ...
Marga, Andrei
core +1 more source
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, EarlyView.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
, 2016 Nunca fue tan claro como en este siglo XXI que saber es poder, algo que las elites siempre supieron. En la Argentina nunca tuvimos aristocracia y hoy ni siquiera tenemos oligarquía, sino sólo una aspiración elitista de alguna riqueza concentrada que sintetiza su pensamiento bajo el lema de no avivar giles. La polarización del siglo XX está sepultada en
openaire +1 more source
Advanced Science, EarlyView.Inspired by the mimosa, this study develops a flexible triboelectric nanogenerator with a novel microneedle array and battery‐mimetic architecture. The device introduces a spontaneous charge self‐regulation mechanism that confines the electric field below the air breakdown threshold, and achieves an outstanding charge density of 396.50 µC m−2 ...
Hanpeng Gao +7 more
wiley +1 more source
Revista de la Facultad de Medicina, 1939 La interpretación de la norma universitaria, es la de que la institución debe acomodarse al medio, es decir: desarrollar la inteligencia de las generaciones imprimiéndoles un carácter de conjunto y de aplicación de las enseñanzas, adaptándolas al adelanto de la sociedad en que se vive, para redimir al hombre de la ignorancia, civilizarlo, capacitarlo ...
openaire +2 more sources
Novos paradigmas na educacão online com a aprendizagem aberta [PDF]
, 2007 This paper aims to discuss important concepts related to online education which bring a new educational paradigm: open learning through free learning materials and technologies.
Okada, Alexandra
core
Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity
Advanced Science, EarlyView.This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao +11 more
wiley +1 more source
ONDE ESTÃO AS UNTI DAS UNIVERSIDADES PÚBLICAS FEDERAIS DO BRASIL [PDF]
, 2017 O presente artigo tem como objetivo apresentar o mapeamento das Universidades Públicas Federais brasileiras que têm “Universidades da Terceira Idade” em suas ações Institucionais.
Rocha, Rudimar Antunes da +2 more
core
Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound
Advanced Science, EarlyView.Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García +11 more
wiley +1 more source