Results 51 to 60 of about 1,739,293 (298)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Drug Delivery, 2019 In this study, the novel carrier materials were screened to structure targeting nano-micelles (named ‘nano-dandelion’) for synchronous delivery of curcumin (Cur) and baicalin (Bai), which could effectively overcome the tumor resistance. Mannose (Man) was
Bingjie Wang +6 more
doaj +1 more source
Ultrasonic irrigation in the removal of smear layer and Enterococcus faecalis from root canals
Brazilian Journal of Oral Sciences, 2015 Aim: This study evaluated both smear layer removal and reduction of Enterococcus faecalis after instrumentation with ultrasonic irrigation. Methods: Root canals were experimentally inoculated with E.
Letícia Maria Menezes Nóbrega +4 more
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Scientific Reports, 2023 In addition to genetic adaptative mechanisms, plants retrieve additional help from the surrounding microbiome, especially beneficial bacterial strains (PGPB) that contribute to plant fitness by modulating plant physiology to fine-tune adaptation to ...
Estrella Galicia-Campos +4 more
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Escuela Abierta, 2023 El presente estudio pretende conocer los hábitos lectores de los jóvenes de Educación Secundaria, reflexionar sobre su percepción de la literatura, detectar los problemas que encuentran al abordar una obra literaria y plantear propuestas de mejora desde
Natalia Agulló Jiménez +2 more
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Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
The role of transient plasma photonic structures in plasma-based amplifiers
Communications Physics, 2023 High power short pulse lasers are technologically reaching a limit in term of amplification due to the material damage threshold of amplifying media. The authors conduct experiments and numerical simulations to show the possibility of benefiting from ...
Grégory Vieux +15 more
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A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Drug Delivery, 2019 Stability in systemic circulation, effective tumor accumulation, and the subsequent crucial subcellular targeting are significant elements that maximize the therapeutic efficacy of a drug.
Lei Fang +6 more
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