Results 231 to 240 of about 94,324,018 (312)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comorbidities and Patient Outcomes in Carbapenem-Resistant Gram-negative Bacterial Infections. [PDF]

Open Forum Infect Dis
Jabbour JF, Li Y, Boutzoukas AE, Hanson B, Doi Y, Cober E, Herc E, Komarow L, Munita JM, Stryjewski ME, Arias CA, Paterson DL, Satlin MJ, Fowler VG, Bonomo RA, van Duin D, Antibacterial Resistance Leadership Group, Antibacterial Resistance Leadership Group .   +17 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

High rate of Healthcare Associated Infections in a Nigerian Tertiary Hospital: A Point Prevalence Survey Highlighting Neonatal and Paediatric Vulnerability. [PDF]

Niger Med J
Sabitu MZ, Mohammed Y, Oduyebo OO, Yusuf T, Nwafia IN, Isa Musa IW, Aljannare BG, Abubakar J, Saminu Y, Dada KM, Mathew H, Faruk U, Versporten A.   +12 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Corrigendum to 'Phase II study of trastuzumab-pkrb plus gedatolisib in patients with HER2-positive metastatic breast cancer who progressed after two or more HER2-directed therapies': [ESMO Open Volume 11, Issue 7, July 2026, 107706]. [PDF]

ESMO Open
Kim JW, Park YH, Lee S, Ahn HK, Bae J, Park S, Chae H, Kim JH, Lee KH, Kim MH, Lee KE, Kang MJ, Park IH, Chae YS, Lee GW, Park KU, Lee EM, Park JH, Kim JE, Kim HJ, Kim TH, Oh SY, Ko S, Byun JH, Ha JY, Kwon JH, Lee S, Choi JY, Jung JY, Park KH.   +29 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prevalence and associated factors of cough syncope in patients with chronic cough: a multicentre prospective study. [PDF]

ERJ Open Res
Jeong J, Kim S, Park HK, Park KE, Lee HY, Kim YC, Kang N, Lee BJ, Lee SE, Jo EJ, Kim SR, Won HK, Park SY, Kang SY, Kim SH, Kim SH, Chang YS, Shin MH, Song WJ, Korean Chronic Cough Registry Investigators, Korean Chronic Cough Registry Investigators .   +20 more
europepmc   +1 more source