Results 241 to 250 of about 40,229,784 (363)

Commentary on Gordon Baskerville's Perspective

open access: yesEcology and Society, 1997
Koichi Fujii
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

volume 14, no. 1 (Spring 2009) [PDF]

open access: yes, 2009
Office of University Advancement, Bryant University
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Author Correction: A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer. [PDF]

open access: yesNat Commun
Wu T   +9 more
europepmc   +1 more source

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