Results 211 to 220 of about 399,173 (303)

The complete genome of the bacterial isolate <i>Pseudomonas</i> sp. WMBT8 isolated from the freshwater fish "deepwater sculpin," a glacial relic. [PDF]

Microbiol Resour Announc
Dailey FE, Kehm A, Phalen A, Essig DA, Vinson MR.   +4 more
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

A genome assembly of the California poppy, Eschscholzia californica. [PDF]

J Hered
Nguyen PT, Escalona M, Ryan E, Miller C, Marimuthu MPA, Fairbairn CW, Seligmann W, Chumchim N, Nguyen O, Toffelmier E, Shaffer HB, Sexton JP, Cleland EE.   +12 more
europepmc   +1 more source

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Manual curation for improved genome annotation of the functionally extinct northern white rhinoceros (Ceratotherium simum cottoni). [PDF]

PLoS One
Ruggeri E, Prunier J, Sirard MA, Durrant B, Klohonatz K.   +4 more
europepmc   +1 more source

Libraries of the University of California

, 1964
openaire   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Shedding Light on PFAS Dark Matter Using a Novel GC-HRMS Approach. [PDF]

Environ Sci Technol
Koelmel JP, Lin EZ, Chang P, Johnson E, Stelben P, Liu S, Nishida K, Tsugawa H, Lin A, Newton S, Casey JS, Nikiforov V, Roberts D, Aksenov A, Okeme J, Metayer C, Vieira VM, Manz KE, Braun JM, Pennell KD, Robey NM, Bangma J, Strynar M, Townsend TG, Bowden JA, Godri Pollitt KJ.   +25 more
europepmc   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Virome profiling of Culex tarsalis through small RNA-seq: A challenge of suboptimal samples. [PDF]

PLoS Negl Trop Dis
Manzano-Alvarez J, Asad S, Chaverra-Rodriguez D, Suh E, Rasgon JL.   +4 more
europepmc   +1 more source