Results 241 to 250 of about 3,464,663 (357)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

MUSC Department of Psychiatry and Behavioral Sciences Psychiatry Residency Training Program, 2016-2017

open access: yes
This photograph features the residents of the Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 2016 ...
Medical University of South Carolina. Department of Psychiatry and Behavioral Sciences
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

MUSC Department of Psychiatry and Behavioral Sciences Psychiatry Residency Training Program, 2013-2014

open access: yes
This photograph features the residents of the Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 2013 ...
Medical University of South Carolina. Department of Psychiatry and Behavioral Sciences
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

MUSC Department of Psychiatry and Behavioral Sciences Psychiatry Residency Training Program, 2011-2012

open access: yes
This photograph features the residents of the Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 2011 ...
Medical University of South Carolina. Department of Psychiatry and Behavioral Sciences
core  

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