Results 121 to 130 of about 1,161,651 (341)

Investigating Macrolactone Formation by Thioesterase Domains through Incorporation of an Unnatural Amino Acid [PDF]

Struct Dyn
Vishakha Choudhary, Tyler M. McCullough, David L. Akey, Meredith A. Skiba, Steffen M. Bernard, Jeffrey D. Kittendorf, Jennifer J. Schmidt, David H. Sherman and Janet L.
Vishakha Choudhary, Tyler M. McCullough, Janet L. Smith   +2 more
europepmc   +2 more sources

A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor [PDF]

, 2008
Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and similar channels constitutes a significant challenge in chemical neurobiology.
Dougherty, Dennis A., Hanek, Ariele P., Lester, Henry A.   +2 more
core  

A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels [PDF]

, 2006
Open-channel blockers such as tetraethylammonium (TEA) have a long history as probes of the permeation pathway of ion channels. High affinity blockade by extracellular TEA requires the presence of an aromatic amino acid at a position that sits at the ...
Ahern, Christopher A., Dougherty, Dennis A., Eastwood, Amy L., Horn, Richard, Lester, Henry A.   +4 more
core   +2 more sources

Experimental Methods for Scanning Unnatural Amino Acid Mutagenesis [PDF]

, 2011
Site-specific incorporation of unnatural amino acids into proteins in vivo relies on the genetic reassignment of nonsense or quadruplet codons. Here, we describe a general procedure for the random introduction of these codons into open reading frames resulting in protein libraries that are scanned with unnatural amino acid residues. These libraries can
Jia, Liu, T Ashton, Cropp
openaire   +2 more sources

Synthesis of rigid p-terphenyl-linked carbohydrate mimetics

Beilstein Journal of Organic Chemistry, 2014
An approach to β-D-2-aminotalose- and β-D-2-aminoidose-configured carbohydrate mimetics bearing a phenyl substituent is described. Unnatural divalent rigid p-terphenyl-linked C-aryl glycosides with 2.0 nm dimension are available using Suzuki cross ...
Maja Kandziora, Hans-Ulrich Reissig
doaj   +1 more source

Synergistic All‐in‐One Electroceutical Platform Utilizing a Plasma–Photodynamic Hybrid Approach for Enhanced Wound Healing

Advanced Functional Materials, EarlyView.
A flexible hybrid patch integrating a robust cold atmospheric plasma (CAP) system with a high‐power, ultrathin bio‐OLED was developed to enable synergistic wound healing. This multimodal therapy, combining plasma and photodynamic treatment, enhanced angiogenesis, cell proliferation, and collagen deposition, demonstrating superior in vivo efficacy and ...
Jun‐Yeop Song, Hyun Cheol Bang, Young Hyun Son, Dae‐In Ha, Eun‐Ju Hong, Sun‐Woo Lee, Jeongsook Kim, Doyeong Kim, Sang‐Min Park, Kyu Pil Lee, Hyo‐Jung Kwon, Jeong Hyun Kwon   +11 more
wiley   +1 more source

Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane [PDF]

, 2015
Lipopolysaccharide (LPS) is a main component of the outer membrane of Gram-negative bacteria, which is essential for the vitality of most Gram-negative bacteria and plays a critical role for drug resistance.
AX Tran, B van den Berg, C Dong, C Whitfield, CC Liu, DJ Sherman, E Freinkman, E Freinkman, EM Hearn, G Malojcic, G Zhang, H Dong, H Hong, H Liu, H Mori, JC Kauer, JC Whitney, JW Chin, KM Schultz, M Grabowicz, MA Khan, MD Suits, N Ruiz, NN Nickerson, P Sperandeo, P Sperandeo, QJ Xiang, R Villa, RE Bishop, RE Bishop, S Okuda, S Okuda, S Qiao, TS Young, Y Gu, Z Wang   +35 more
core   +1 more source

Coacervates Made of Elastin‐Like Polypeptides Fused with Melanocyte‐Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord‐Injured Mice

Advanced Healthcare Materials, EarlyView.
Pressure skin wounds are frequent complications after spinal cord injury (SCI), with impaired healing due to vascular and immune deficits. Elastin‐like polypeptides (ELP) fused to α‐MSH (MSH‐ELP) or MCP‐1 (MCP‐ELP) are developed and tested on these wounds. The resulting nanoparticles are non‐toxic and bioactive, and they enhance macrophage recruitment,
Suneel Kumar, Dhruv Patel, Greeshma Manjunath, Shashank Madhavan, Ashley Mathew, Dnyaneshwari Rananavare, Jahnavi Shah, Francois Berthiaume   +7 more
wiley   +1 more source

A General Route for Post-Translational Cyclization of mRNA Display Libraries [PDF]

, 2005
Cyclic peptides are attractive scaffolds for the design of conformationally constrained molecular therapeutics. Previously, biological display libraries could only be cyclized via disulfide bonds, which are labile and can be reduced in an intracellular ...
Millward, Steven W., Roberts, Richard W., Takahashi, Terry T.   +2 more
core   +1 more source

The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands

Beilstein Journal of Organic Chemistry, 2017
Pentapeptides having the sequence R-HN-Ala-Val-X-Val-Leu-OMe, where the central residue X is L-serine, L-threonine, (2S,3R)-L-CF3-threonine and (2S,3S)-L-CF3-threonine were prepared.
Yaochun Xu, Isabelle Correia, Tap Ha-Duong, Nadjib Kihal, Jean-Louis Soulier, Julia Kaffy, Benoît Crousse, Olivier Lequin, Sandrine Ongeri   +8 more
doaj   +1 more source