Results 291 to 300 of about 1,161,651 (341)

Novel Fluorescence-Based Biosensors Incorporating Unnatural Amino Acids

2017
Fluorescent proteins of different colors are useful probes to study protein structure and function, and to investigate cellular events and conditions. Large efforts have focused on engineering new properties into fluorescent proteins via rational design and directed evolution.
Wei, Niu, Jiantao, Guo
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Applications of Unnatural Amino Acids in Protease Probes

Chemistry – An Asian Journal, 2019
AbstractSince proteases are involved in a wide range of physiological and disease states, the development of novel tools for imaging proteolytic enzyme activity is attracting increasing interest from scientists. Peptide substrates containing proteinogenic amino acids are often the first line of defining enzyme specificity.
Izabela Maluch, Justyna Czarna, Marcin Drag   +2 more
openaire   +2 more sources

Multistep Enzyme Catalyzed Reactions for Unnatural Amino Acids

2011
The use of unnatural amino acids, particularly synthetic α-amino acids, for modern drug discovery research requires the availability of enantiomerically pure isomers. Starting from a racemate, one single enantiomer can be obtained using a deracemization process.
D'ARRIGO, PAOLA, TESSARO, DAVIDE
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Protein and Cellular Engineering with Unnatural Amino Acids

Biotechnology Progress, 2007
Abstract Proteins are the central functional constituents in all living organisms ranging from viruses, bacteria, yeast, and plants to mammals. All of these biopolymers that are formed by natural biosynthetic pathways are composed of a genetically determined sequence of the 20 so‐called natural amino acids.
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Unnatural α-amino acid synthesis

Nature Synthesis, 2023
Tuan Anh Trinh, Jennifer M. Schomaker
openaire   +1 more source

Unnatural Amino Acids for Biological Spectroscopy and Microscopy

Chemical Reviews
Due to advances in methods for site-specific incorporation of unnatural amino acids (UAAs) into proteins, a large number of UAAs with tailored chemical and/or physical properties have been developed and used in a wide array of biological applications. In particular, UAAs with specific spectroscopic characteristics can be used as external reporters to ...
Ran-ran Feng, Manxi Wang, Wenkai Zhang, Feng Gai   +3 more
openaire   +2 more sources

Virus-Enabled Optimization and Delivery of the Genetic Machinery for Efficient Unnatural Amino Acid Mutagenesis in Mammalian Cells and Tissues.

ACS Synthetic Biology, 2017
Yunan Zheng, Tommy L. Lewis, P. Igo, F. Polleux, A. Chatterjee   +4 more
semanticscholar   +1 more source

Synthesis, photophysical properties of triazolyl-donor/acceptor chromophores decorated unnatural amino acids: Incorporation of a pair into Leu-enkephalin peptide and application of triazolylperylene amino acid in sensing BSA.

Bioorganic & Medicinal Chemistry, 2016
S. Bag, S. Jana, M. Pradhan
semanticscholar   +1 more source

Unnatural Amino Acid Synthesis Enabled by the Regioselective Cobalt(III)-Catalyzed Intermolecular Carboamination of Alkenes.

Angewandte Chemie, 2016
Andreas Lerchen, T. Knecht, C. Daniliuc, F. Glorius   +3 more
semanticscholar   +1 more source

Lanthanoid tagging via an unnatural amino acid for protein structure characterization

Journal of Biomolecular NMR, 2017
Wen-xue Jiang, Xin-Hua Gu, Xu Dong, Chun Tang   +3 more
semanticscholar   +1 more source