Results 81 to 90 of about 25,937 (249)

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Morphological and phylogeny of Plenodomus sinensis and P. collinsoniae, two unreported species isolated from soil in Korea

한국균학회지, 2020
Two unreported fungal isolates, KNU-GW1901 and KNU-AP100C, were collected from soil sample in Gyeongsangbuk-do, Korea. Their cultural and morphological characteristics were examined after 4 weeks of incubation at 25℃ on potato dextrose agar (PDA), malt extract agar (MEA), and oatmeal agar (OA).
Than Naing Moe, Kallol Das, In-Kyu Kang, Seung-Yeol Lee, Hee-Young Jung   +4 more
openaire   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

<b>A first record of three hitherto unreported species of bats from Kerala, India with a note on <I>Myotis peytoni</I> (Mammalia: Chiroptera: Vespertilionidae)</b>

Journal of Threatened Taxa, 2017
We provide specimen-based evidence and echolocation calls of an additional three species of bats in Kerala, India. A brief note on the taxonomy and nomenclature of Peyton’s Whiskered Myotis, and an updated checklist of bats of Kerala is also included.
Bhargavi Srinivasulu, Chelmala Srinivasulu   +1 more
openaire   +2 more sources

Systematic Cardiac Phenotyping of Patients With Copy Number Variants in the 15q11.2 Breakpoint 1 to Breakpoint 2 Region: A Retrospective Cohort Study From Nine Pediatric Cardiac Centers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Microdeletions impacting 15q11.2 breakpoint (BP) 1 to BP2, adjacent to the Prader–Willi critical region, have previously described neuropsychiatric associations, with potential low penetrance presentations of congenital heart disease (CHD) also identified.
Morgan B. Wright, Maria B. Padua, Lindsey R. Helvaty, Kim L. McBride, Gabrielle Geddes, Vidu Garg, Seema R. Lalani, Stephanie Burns Wechsler, Jennelle C. Hodge, Benjamin J. Landis, Stephanie M. Ware   +10 more
wiley   +1 more source

Methylome Analysis of Two Xanthomonas spp. Using Single-Molecule Real-Time Sequencing

The Plant Pathology Journal, 2016
Single-molecule real-time (SMRT) sequencing allows identification of methylated DNA bases and methylation patterns/motifs at the genome level. Using SMRT sequencing, diverse bacterial methylomes including those of Helicobacter pylori, Lactobacillus spp.,
Hoon Je Seong, Hye-Jee Park, Eunji Hong, Sung Chul Lee, Woo Jun Sul, Sang-Wook Han   +5 more
doaj   +1 more source

Application of Environmental DNA Metabarcoding to Differentiate Algal Communities by Littoral Zonation and Detect Unreported Algal Species

Phycology
Coastal areas are the most biologically productive and undoubtedly among the most complex ecosystems. Algae are responsible for most of the gross primary production in these coastal regions. However, despite the critical importance of algae for the global ecosystem, the biodiversity of many algal groups is understudied, partially due to the high ...
Sergei Bombin, Andrei Bombin, Brian Wysor, Juan M. Lopez-Bautista   +3 more
openaire   +3 more sources

A new species of Olixon Cameron, 1887 (Hymenoptera, Rhopalosomatidae) from southeastern Brazil [PDF]

Papéis Avulsos de Zoologia
A new species of the brachypterous wasp genus Olixon Cameron, 1887 is described and illustrated from southeastern Brazil. Olixon pluviatenuis sp. nov. is described based on a single male specimen collected in the Oswaldo Cruz Botanical Garden, São Paulo,
Rogério Botion Lopes, Mayara Medeiros Bulbol   +1 more
doaj   +2 more sources

First record of Bibrax Fletcher, 1927 (Coleoptera, Staphylinidae, Pselaphinae) from Ecuador, with descriptions of twelve new species [PDF]

ZooKeys
Twelve new species of Bibrax Fletcher, 1927 (Coleoptera: Staphylinidae: Pselaphinae: Euplectitae: Metopiasini) from Ecuador are described: B. chullachaqui sp. nov., B. chocoensis sp. nov., B. onorei sp. nov., B. aratrifer sp. nov., B. longiventer sp. nov.
Yarina Tapuy-Avilés, David R. Díaz-Guevara, Michael S. Caterino   +2 more
doaj   +3 more sources