Results 51 to 60 of about 4,184,881 (309)
工程科学与技术, 2022 Sichuan—Tibet railway is in the topographic crossing zone from the Sichuan basin to Qinghai Tibet Plateau. Regional characteristic geological factors such as active structure, valley unloading and freeze-thaw weathering along the line have strong control
Guangze ZHANG +4 more
doaj
Mathematical Modelling and Analysis, 2008 Piecewise polynomial collocation methods on special nonuniform grids are efficient methods for solving weakly singular Fredholm and Volterra integral equations but there is a widespread belief that those methods are numerically unstable in the case of ...
Raul Kangro, Inga Kangro
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Impact of flux jumps in future colliders
Physical Review Accelerators and Beams, 2020 Type-II superconductors, like the Nb_{3}Sn used in the new HL–LHC quadrupole triplet and 11 T dipoles or FCC dipoles, are known to show an unstable behavior during magnetic-field ramps.
J. Coello de Portugal +4 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Cellular automaton simulation of counter flow with paired pedestrians [PDF]
International Journal of Computational Intelligence Systems, 2011 Knowledge on pedestrian behavior is the basis to build decision support system for crowd evacuation management in emergency. In this paper, the impact of paired walking behavior on pedestrian counter flow in a channel is studied.
Hui Xiong +4 more
doaj +1 more source
On the Quantum Deviations from Einstein Dilation of Unstable Quanton* Decay Evolution and Lifetimes [PDF]
, 2011 For over a decade several workers have argued for the existence of quantum deviations from the classical, Einstein dilation of the decay evolution of moving or Lorentz boosted unstable particles.
Fleming, Gordon / N
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Influence of type A behavioral activity on the development of cardiovascular disease
КардиоСоматика, 2019 Aim. To study the influence of type of behavioral activity on the development of cardiovascular diseases, to evaluate the effect of type of behavior on the frequency of repeated hospitalizations and fatal outcomes after acute coronary syndrome. Materials
Anatoly I. Martynov +4 more
doaj +1 more source
Depth Dependence and Keyhole Stability at Threshold, for Different Laser Welding Regimes
Applied Sciences, 2020 Depending of the laser operating parameters, several characteristic regimes of laser welding can be observed. At low welding speeds, the aspect ratio of the keyhole can be rather large with a rather vertical cylindrical shape, whereas at high welding ...
Remy Fabbro
doaj +1 more source