Results 41 to 50 of about 815,331 (254)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Physical Review ResearchWe present direct experimental evidence for turbulence visiting the neighborhoods of simple invariant solutions in phase space, immediately preceding and during rapid transitions between metastable flow regimes characterized by opposite large-scale ...
B. Vishnu Kiran +2 more
doaj +1 more source
Известия высших учебных заведений: Нефть и газ, 2015 The paper presents the technique for improvement of heat pipelines thermohydraulic regimes under the unstable heat consumption conditions. Different schemes of connection of heat consumers to the heat network are considered and analyzed.
Yu. D. Zemenkov +3 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
(Oscillating) non-exponential decays of unstable states [PDF]
, 2012 We discuss deviations from the exponential decay law which occur when going beyond the BreitWigner distribution for an unstable state. In particular, we concentrate on an oscillating behavior, remisiscent of the Rabi-oscillations, in the short-time ...
Giacosa, Francesco, Pagliara, Giuseppe
core
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Dynamical persistence in high-diversity resource-consumer communities.
PLoS Computational Biology, 2020 We show how highly-diverse ecological communities may display persistent abundance fluctuations, when interacting through resource competition and subjected to migration from a species pool. These fluctuations appear, robustly and predictably, in certain
Itay Dalmedigos, Guy Bunin
doaj +1 more source
Performance of a Modified Negative Branch Unstable Resonator [PDF]
, 2007 Far field deployment of high power chemical oxygen iodine laser (COIL) affords optimally adapted resonator architectures. Such resonators shall enable high brightness operation.
Grünewald, Karin +4 more
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Fundamental Shift From Summer to Winter of Holocene Rainfall Regime in the Tropics
Geophysical Research Letters, 2023 The seasonal rainfall regime is a key factor control on local ecological and social processes and is commonly thought to be stable under long‐term climate changes.
Jianghu Lan +16 more
doaj +1 more source