Results 41 to 50 of about 16,628 (253)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Regime dependent instability as a transition mechanism in large-scale atmospheric flow

Annals of Geophysics, 2000
Two apparently distinct approaches to studying the observed low frequency variability in the atmosphere have evolved over the past few years. One approach invokes multiple, recurrent flow regimes to explain the observed variability.
I. Bordi
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Observing Rayleigh–Taylor Stable and Unstable Accretion Through a Kalman Filter Analysis of X-Ray Pulsars in the Small Magellanic Cloud

The Astrophysical Journal
Global, three-dimensional magnetohydrodynamic simulations of Rayleigh–Taylor instabilities at the disk–magnetosphere boundary of rotating, magnetized compact stellar objects reveal that accretion occurs in three regimes: the stable regime, the chaotic ...
Joseph O’Leary, Andrew Melatos, Tom Kimpson, Dimitris M. Christodoulou, Nicholas J. O’Neill, Patrick M. Meyers, Sayantan Bhattacharya, Silas G.T. Laycock   +7 more
doaj   +1 more source

Atmospheric Boundary Layer Stability in Urban Beijing: Insights from Meteorological Tower and Doppler Wind Lidar

Remote Sensing
The limited understanding of the structure of the urban surface atmospheric boundary layer can be attributed to its inherent complexity, as well as a deficiency in comprehensive measurements.
Linlin Wang, Bingcheng Wan, Yuanjian Yang, Sihui Fan, Yi Jing, Xueling Cheng, Zhiqiu Gao, Shiguang Miao, Han Zou   +8 more
doaj   +1 more source

Entanglement of stationary states in the presence of unstable quasiparticles

Journal of High Energy Physics, 2023
The effect of unstable quasiparticles in the out-of-equilibrium dynamics of certain integrable systems has been the subject of several recent studies.
Dávid X. Horváth, Pasquale Calabrese, Olalla A. Castro-Alvaredo   +2 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Experimental evidence for invariant solutions mediating transitions from metastable turbulent regimes

Physical Review Research
We present direct experimental evidence for turbulence visiting the neighborhoods of simple invariant solutions in phase space, immediately preceding and during rapid transitions between metastable flow regimes characterized by opposite large-scale ...
B. Vishnu Kiran, Rajath Kashyap, Balachandra Suri   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

IMPROVEMENT OF THERMOHYDRAULIC REGIMES OF HEAT PIPELINES IN THE CONDITIONS OF UNSTABLE HEAT CONSUMPTION

Известия высших учебных заведений: Нефть и газ, 2015
The paper presents the technique for improvement of heat pipelines thermohydraulic regimes under the unstable heat consumption conditions. Different schemes of connection of heat consumers to the heat network are considered and analyzed.
Yu. D. Zemenkov, B. V. Moiseev, N. V. Nalobin, S. M. Dudin   +3 more
doaj   +1 more source