Results 171 to 180 of about 1,715,429 (285)

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa. [PDF]

Am J Respir Crit Care Med
Cummings MJ, Lutwama JJ, Owor N, Tomoiaga AS, Ross JE, Muwanga M, Nsereko C, Nayiga I, Kyebambe S, Shinyale J, Ochar T, Kiwubeyi M, Nankwanga R, Nie K, Xie H, Miake-Lye S, Villagomez B, Qi J, Reynolds SJ, Nakibuuka MC, Lu X, Kayiwa J, Haumba M, Nakaseegu J, Che X, Wayengera M, Ghosh S, Kim-Schulze S, Lipkin WI, Bakamutumaho B, O'Donnell MR.   +30 more
europepmc   +1 more source

Unsupervised classification of multi-omics data during cardiac remodeling using deep learning. [PDF]

Methods, 2019
Chung NC, Mirza B, Choi H, Wang J, Wang D, Ping P, Wang W.   +6 more
europepmc   +1 more source

Author Correction: Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint. [PDF]

Nat Commun
Wheeler DW, Banduri S, Sankararaman S, Vinay S, Ascoli GA.   +4 more
europepmc   +1 more source

Unsupervised Classification During Time-Series Model Building. [PDF]

Multivariate Behav Res, 2017
Gates KM, Lane ST, Varangis E, Giovanello K, Guskiewicz K.   +4 more
europepmc   +1 more source

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint. [PDF]

Nat Commun
Wheeler DW, Banduri S, Sankararaman S, Vinay S, Ascoli GA.   +4 more
europepmc   +1 more source

Unsupervised classification of SARS-CoV-2 genomic sequences uncovers hidden genetic diversity and suggests an efficient strategy for genomic surveillance

, 2021
Chiara M, Horner DS, Ferrandi E, Gissi C, Pesole G.   +4 more
europepmc   +1 more source

Blood Vessel Extraction in Color Retinal Fundus Images with Enhancement Filtering and Unsupervised Classification. [PDF]

J Healthc Eng, 2017
Yavuz Z, Köse C.
europepmc   +1 more source