Results 191 to 200 of about 95,703 (260)

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Digital Motor Profiling in Parkinson's Disease: Long-Term Monitoring Through Wearable Sensors. [PDF]

Brain Sci
Zampogna A, Borzì L, Rinaldi D, Imbalzano G, Patera M, Falletti M, Artusi CA, Pauletti C, Bianchini E, Lopiano L, Olmo G, Suppa A.   +11 more
europepmc   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Machine Learning Approach for Cardiovascular Disease Risk Stratification Using Ensemble Classifiers and Dimensionality Reduction. [PDF]

Life (Basel)
Posada-Castellanos A, Gomez-Aristizabal MA, Orrego-Franco CM, Restrepo-Parra E, Lopez-Betancur LE.   +4 more
europepmc   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

A Two-Stage Classification Method for Improved Fault Detection in Wind Turbines Based on SCADA Data. [PDF]

Sensors (Basel)
Dai J, Rotea M, Kehtarnavaz N.
europepmc   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Supervised and covariate-adjusted dimension reduction for prediction and visualization using microbiome data. [PDF]

Brief Bioinform
Zang C, Tang L, Deek RA.
europepmc   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

Genomic characterization of aggressiveness in pituitary neuroendocrine tumors. [PDF]

Neuro Oncol
Benanteur N, Villa C, Bioletto F, Birtolo MF, De Murat D, Masliah-Planchon J, Gravrand V, Lebib I, Benkhellat M, Boezennec R, Allassonnière S, Letourneur F, Martin Y, Bonnet Serrano F, Jacob J, Calugaru V, Barat M, Dohan A, Arrondeau J, Huillard O, Raffin-Sanson ML, Emile JF, Raverot G, Libé R, Guignat L, Garcia C, Groussin L, Bertagna X, Gaillard S, Bertherat J, Jouinot A, Baussart B, Assié G.   +32 more
europepmc   +1 more source