Results 61 to 70 of about 246,994 (340)
MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers. [PDF]
PLoS ONE, 2012 MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer.
Georgina L Ryland +9 more
doaj +1 more source
Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies [PDF]
, 2011 We have used high-throughput Illumina sequencing to identify novel recombinants between deformed wing virus (DWV) and Varroa destructor virus-1 (VDV-1), which accumulate to higher levels than DWV in both honeybees and Varroa destructor mites.
A. Jironkin +20 more
core +1 more source
The role of the 5′ untranslated regions of Potyviridae in translation
Virus Research, 2015 The Potyviridae family relies on a cap-independent translation mechanism to facilitate protein expression. The genomic architecture of the viral RNAs of the Potyviridae family resembles those of the animal picornaviruses. The viral genomes lack a 5' cap structure. Instead, they have the viral protein VPg covalently linked to the 5' end of the RNA.
Robyn Roberts +2 more
openaire +2 more sources
Transcriptional Repression, a Novel Function for 3' Untranslated Regions [PDF]
European Journal of Biochemistry, 1995 The transcription rates of the rat serine protease inhibitor 2.3 and 2.1 genes (spi 2.3 and spi 2.1), which are normally very low and high, respectively, are inversely modulated during inflammation. Two growth‐hormone‐response elements (GHRE‐I and GHRE‐II) maintain the spi 2.1 gene under the stringent control of growth hormone [Le Cam, A., Pantescu, V.,
Catherine Legraverend, Alphonse Le Cam
openaire +4 more sources
Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences
Frontiers in Chemistry, 2021 The ongoing COVID-19/Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) pandemic has become a significant threat to public health and has hugely impacted societies globally.
Shalakha Hegde +3 more
doaj +1 more source
The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity [PDF]
Frontiers in Microbiology, 2018 Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute to initiation and progression of disease.
Devendra K. Rai +2 more
openaire +4 more sources
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
PLoS Neglected Tropical Diseases, 2022 The parasite Trypanosoma brucei grows as bloodstream forms in mammalian hosts, and as procyclic forms in tsetse flies. In trypanosomes, gene expression regulation depends heavily on post-transcriptional mechanisms.
Tania Bishola Tshitenge +3 more
doaj +1 more source
Messenger RNA targeting to endoplasmic reticulum stress signalling sites. [PDF]
, 2009 Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic cells lead to ER stress and trigger the unfolded protein response (UPR).
Aragón, Tomás +6 more
core
Characterization of 3'-untranslated region of the mouse GDNF gene [PDF]
BMC Molecular Biology, 2012 Abstract Background Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for many cell types, and its expression is widespread both within and outside of the nervous system. The regulation of GDNF expression has been extensively investigated but is not fully understood.
Yoko Hirata +2 more
openaire +2 more sources