Results 61 to 70 of about 249,320 (341)
The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein [PDF]
, 1992 An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated.
Honka, Thomas +4 more
core +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
The role of the 5′ untranslated regions of Potyviridae in translation
Virus Research, 2015 The Potyviridae family relies on a cap-independent translation mechanism to facilitate protein expression. The genomic architecture of the viral RNAs of the Potyviridae family resembles those of the animal picornaviruses. The viral genomes lack a 5' cap structure. Instead, they have the viral protein VPg covalently linked to the 5' end of the RNA.
Robyn Roberts +2 more
openaire +2 more sources
The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity [PDF]
Frontiers in Microbiology, 2018 Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute to initiation and progression of disease.
Devendra K. Rai +2 more
openaire +4 more sources
PLoS Neglected Tropical Diseases, 2022 The parasite Trypanosoma brucei grows as bloodstream forms in mammalian hosts, and as procyclic forms in tsetse flies. In trypanosomes, gene expression regulation depends heavily on post-transcriptional mechanisms.
Tania Bishola Tshitenge +3 more
doaj +1 more source
Messenger RNA targeting to endoplasmic reticulum stress signalling sites. [PDF]
, 2009 Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic cells lead to ER stress and trigger the unfolded protein response (UPR).
Aragón, Tomás +6 more
core
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Characterization of 3'-untranslated region of the mouse GDNF gene [PDF]
BMC Molecular Biology, 2012 Abstract Background Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for many cell types, and its expression is widespread both within and outside of the nervous system. The regulation of GDNF expression has been extensively investigated but is not fully understood.
Yoko Hirata +2 more
openaire +2 more sources
Characterization of Single Nucleotide Variants of OPN3 Gene in Melanocytic Nevi and Melanoma
JID Innovations, 2021 In this study, we examined single nucleotide variants (SNVs) of the OPN3 gene in malignant melanoma and melanocytic nevi. A total of 20 variants of SNVs were detected.
Wei Zhang +5 more
doaj
Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene [PDF]
, 2006 Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined and is associated with high (H) and low (L) expression alleles identified by a HindIII restriction fragment-length polymorphism (RFLP) in intron 27 of the CR1 gene ...
Cockburn I.A. +8 more
core +1 more source