Results 41 to 50 of about 164,097 (264)
Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5′ Untranslated Region
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Vascular smooth muscle cell phenotypic change and consequential intimal hyperplasia (IH) cause arterial stenosis and posttreatment restenosis.
Xiujie Xie +5 more
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Expression of versican 3'-untranslated region modulates endogenous microRNA functions. [PDF]
PLoS ONE, 2010 Mature microRNAs (miRNAs) are single-stranded RNAs that regulate post-transcriptional gene expression. In our previous study, we have shown that versican 3'UTR, a fragment of non-coding transcript, has the ability to antagonize miR-199a-3p function ...
Daniel Y Lee +9 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
UTRme: A Scoring-Based Tool to Annotate Untranslated Regions in Trypanosomatid Genomes
Frontiers in Genetics, 2018 Most signals involved in post-transcriptional regulatory networks are located in the untranslated regions (UTRs) of the mRNAs. Therefore, to deepen our understanding of gene expression regulation, delimitation of these regions with high accuracy is ...
Santiago Radío +8 more
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Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences
Frontiers in Chemistry, 2021 The ongoing COVID-19/Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) pandemic has become a significant threat to public health and has hugely impacted societies globally.
Shalakha Hegde +3 more
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3′untranslated regions: regulation at the end of the road
Current Genetics, 2018 Post-transcriptional gene regulation in bacteria plays a major role in the adaptation of bacterial cells to the changing conditions encountered in the environment. In bacteria, most of the regulation at the level of mRNA seems to be targeting the 5'untranslated regions where accessibility to the ribosome-binding site can be modulated to alter gene ...
Youssef El Mouali, Carlos Balsalobre
openaire +3 more sources
Regulation of CCN1 via the 3′-untranslated region [PDF]
Journal of Cell Communication and Signaling, 2013 The 3'-untranslated region (UTR) is known to be a critical regulator of post-transcriptional events that determine the gene expression at the RNA level. The gene CCN1 is one of the classical members of the matricellular CCN family and is involved in a number of biological processes during mammalian development.
Yosuke, Nakagawa +8 more
openaire +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.
PLoS ONE, 2014 Eukaryotic cells control their growth and morphogenesis to maintain integrity and viability. Free-living cells are further challenged by their direct interaction with the environment and in many cases maintain a resilient cell wall to stay alive under ...
Antony G Wanless, Yuan Lin, Eric L Weiss
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Viruses, 2019 We previously generated a recombinant reporter Akabane virus expressing enhanced green fluorescence protein (eGFP-AKAV), with an artificial S genome encoding eGFP in the ambisense RNA.
Akiko Takenaka-Uema +6 more
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