Results 31 to 40 of about 164,097 (264)
Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]
PLoS ONE, 2011 In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi +4 more
doaj +1 more source
Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2
Virulence, 2022 It was noticed that the mortality rate of SARS-CoV-2 infection experienced a significant declination in the early stage of the epidemic. We suspect that the sharp deterioration of virus toxicity is related to the deletion of the untranslated region (UTR)
Zhaobin Xu +3 more
doaj +1 more source
Journal of Lipid Research, 2009 The 3′untranslated region (UTR) of human LDL receptor (LDLR) mRNA contains three AU-rich elements (AREs) responsible for rapid mRNA turnover and mediates the stabilization induced by berberine (BBR).
Hai Li +7 more
doaj +1 more source
The RNA Architecture of the SARS-CoV-2 3′-Untranslated Region
Viruses, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3′ untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication ...
Junxing Zhao +4 more
doaj +1 more source
Evolution of the influenza A virus untranslated regions
Infection, Genetics and Evolution, 2011 In case of the influenza virus, untranslated regions are considered to possess plural functions. The specific packaging model suggests that each of eight segments contains a unique "packaging signal", situated within the untranslated region and coding regions at the 5' and 3' ends of the genomic RNA. In addition to packaging signal, UTRs play key roles
Yuki, Furuse, Hitoshi, Oshitani
openaire +2 more sources
Molecular Therapy: Nucleic Acids, 2015 Short noncoding (snc)RNAs are important new players in the landscape of biologics with therapeutic potential. Recently, we reported on a new method for the synthesis and delivery of snc RNA in B-cells transfected with plasmid DNA.
Gonzalo Almanza, Maurizio Zanetti
doaj +1 more source
Host tRNA-Derived RNAs Target the 3′Untranslated Region of SARS-CoV-2
Pathogens, 2022 The COVID-19 pandemic revealed a need for new understanding of the mechanisms regulating host–pathogen interactions during viral infection. Transfer RNA-derived RNAs (tDRs), previously called transfer RNA fragments (tRFs), have recently emerged as ...
Emily N. Hendrickson +2 more
doaj +1 more source
Regulatory 3′ Untranslated Regions of Bacterial mRNAs [PDF]
Frontiers in Microbiology, 2017 The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression. Most studies of bacterial UTRs have focused on the 5'regions; however, 3'UTRs have recently emerged as a new class of post-transcriptional regulatory elements.
Ren, Gai-Xian +2 more
openaire +3 more sources
Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. [PDF]
PLoS ONE, 2013 The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases.
Marcel Kramer +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source