Results 11 to 20 of about 164,097 (264)
The ODC 3′-Untranslated Region and 5′-Untranslated Region Contain cis-Regulatory Elements: Implications for Carcinogenesis [PDF]
Medical Sciences, 2017 It has been hypothesized that both the 3′-untranslated region (3′UTR) and the 5′-untranslated region (5′UTR) of the ornithine decarboxylase (ODC) mRNA influence the expression of the ODC protein. Here, we use luciferase expression constructs to examine the influence of both UTRs in keratinocyte derived cell lines. The ODC 5′UTR or 3′UTR was cloned into
Shannon Nowotarski, Lisa Shantz
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Optimization of the 5' untranslated region of mRNA vaccines. [PDF]
Sci RepTo investigate the impact of different 5' untranslated regions (UTRs) on mRNA vaccine translation efficiency, five dual-reporter gene expression plasmids with different 5'UTRs were constructed. The corresponding mRNA transcripts were transcribed and capped in vitro.
Ma Q +5 more
europepmc +4 more sources
Internal ribosomal entry site-mediated translational activity of nitric oxide synthase 2
Animal Cells and Systems, 2023 The internal ribosome entry site (IRES) is a unique structure found in the 5’ untranslated region (5'-UTR) of specific messenger RNAs (mRNAs) that allows ribosomes to bind and initiate translation without the need for a cap structure.
Kyung-Ha Lee
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Importance of the 5' untranslated region for recombinant enzyme production in isolated Bacillus subtilis 007. [PDF]
AMB ExpressThe production of industrial enzymes requires an efficient expression system with a suitable host. This study investigated the isolated Bacillus subtilis 007 as a host for expressing three enzymes with potential application in the food industry. Firstly,
Senger J +4 more
europepmc +2 more sources
Frontiers in Microbiology, 2021 The untranslated region (UTRs) of viral genome are important for viral replication and immune modulation. Japanese encephalitis virus (JEV) is the most significant cause of epidemic encephalitis worldwide.
Hong Liu +4 more
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Translating the Untranslated Region [PDF]
The Journal of Immunology, 2015 Abstract Gene expression programs undergo constant regulation to quickly adjust to environmental stimuli that alter the physiological status of the cell, like cellular stress or infection. Gene expression is tightly regulated by multilayered regulatory elements acting in both cis and trans.
Johannes, Schwerk, Ram, Savan
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Frontiers in Immunology, 2021 Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger RNA (mRNA) metabolism pathways. The ZFP36 family is composed of ZFP36 (
Sohei Makita +3 more
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Conserved Sequences in the 5′ and 3′ Untranslated Regions of Jingmenvirus Group Representatives
Viruses, 2023 The Jingmenvirus group (JVG), with members such as Jingmen tick virus (JMTV), Alongshan virus (ALSV), Yanggou tick virus (YGTV), and Takachi virus (TAKV), is drawing attention due to evidence of it causing disease in humans and its unique genome ...
Alexander G. Litov +4 more
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The Untranslated Regions of mRNAs in Cancer [PDF]
Trends in Cancer, 2019 The 5' and 3' untranslated regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary for the maintenance of cellular homeostasis. When these processes go awry through mutation or misexpression of certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or enhance cancer ...
Samantha L, Schuster, Andrew C, Hsieh
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Characterization of Single Nucleotide Variants of OPN3 Gene in Melanocytic Nevi and Melanoma
JID Innovations, 2021 In this study, we examined single nucleotide variants (SNVs) of the OPN3 gene in malignant melanoma and melanocytic nevi. A total of 20 variants of SNVs were detected.
Wei Zhang +5 more
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