Structural diversity and biological role of the 5’ untranslated regions of picornavirus [PDF]
RNA Biology, 2023 The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature.
Tingyu Peng +5 more
doaj +3 more sources
Evidence for widespread translation of 5′ untranslated regions [PDF]
Nucleic Acids ResearchAbstract Ribosome profiling experiments support the translation of a range of novel human open reading frames. By contrast, most peptides from large-scale proteomics experiments derive from just one source, 5′ untranslated regions. Across the human genome we find evidence for 192 translated upstream regions, most of which would produce ...
JOSÉ Manuel Rodríguez +2 more
exaly +5 more sources
The Untranslated Regions of mRNAs in Cancer [PDF]
Trends in Cancer, 2019 The 5' and 3' untranslated regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary for the maintenance of cellular homeostasis. When these processes go awry through mutation or misexpression of certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or enhance cancer ...
Samantha L Schuster, Andrew C Hsieh
exaly +5 more sources
The 5′ and 3′ Untranslated Regions of the Flaviviral Genome [PDF]
Viruses, 2017 Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense RNA genome that can cause serious illness in humans and animals.
Wy Ching Ng +4 more
doaj +5 more sources
How is polyadenylation restricted to 3'-untranslated regions? [PDF]
Yeast, 2023 Polyadenylation occurs at numerous sites within 3’ untranslated regions (3’ UTRs) but rarely within coding regions. How does Pol II travel through long coding regions without generating poly(A) sites, yet then permits promiscuous polyadenylation once it reaches the 3’ UTR?
Struhl K.
europepmc +3 more sources
Properties of untranslated regions of the
BMC Genomics, 2009 Background During evolution selection forces such as changing environments shape the architecture of genomes. The distribution of genes along chromosomes and the length of intragenic regions are basic genomic features known to play a major role in the ...
Tuller Tamir +2 more
doaj +3 more sources
Regulatory 3′ Untranslated Regions of Bacterial mRNAs [PDF]
Frontiers in Microbiology, 2017 The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression.
Gai-Xian Ren +2 more
doaj +3 more sources
Synthetic mRNAs Containing Minimalistic Untranslated Regions Are Highly Functional In Vitro and In Vivo [PDF]
CellsSynthetic mRNA produced by in vitro transcription (ivt mRNA) is the active pharmaceutical ingredient of approved anti-COVID-19 vaccines and of many drugs under development.
Shahab Mamaghani +10 more
doaj +2 more sources
Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes [PDF]
Nature CommunicationsAlthough genome-wide polycistronic transcription places major emphasis on post-transcriptional controls in trypanosomatids, messenger RNA cis-regulatory untranslated regions (UTRs) have remained largely uncharacterised.
Anna Trenaman +3 more
doaj +2 more sources
Conserved Sequences in the 5′ and 3′ Untranslated Regions of Jingmenvirus Group Representatives [PDF]
Viruses, 2023 The Jingmenvirus group (JVG), with members such as Jingmen tick virus (JMTV), Alongshan virus (ALSV), Yanggou tick virus (YGTV), and Takachi virus (TAKV), is drawing attention due to evidence of it causing disease in humans and its unique genome ...
Alexander G. Litov +4 more
doaj +2 more sources