Results 21 to 30 of about 137,203 (272)
Dissecting non-B DNA structural motifs in untranslated regions of eukaryotic genomes [PDF]
Genomics & InformaticsThe untranslated regions (UTRs) of genes significantly impact various biological processes, including transcription, posttranscriptional control, mRNA stability, localization, and translation efficiency.
Aruna Sesha Chandrika Gummadi +2 more
doaj +2 more sources
Dom34 Rescues Ribosomes in 3′ Untranslated Regions [PDF]
Cell, 2014 Ribosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is unknown. Here, we extend ribosome profiling methodology to reveal a high-resolution molecular characterization
Nicholas R Guydosh, Rachel Green
exaly +3 more sources
Frontiers in VirologyTombusviridae is a large family of single-stranded, positive-sense RNA plant viruses with uncapped, non-polyadenylated genomes encoding 4–7 open reading frames (ORFs).
Zachary Lozier +5 more
doaj +3 more sources
LncRNAs and Chromatin Modifications Pattern m6A Methylation at the Untranslated Regions of mRNAs [PDF]
Frontiers in Genetics, 2022 New roles for RNA in mediating gene expression are being discovered at an alarming rate. A broad array of pathways control patterning of N6-methyladenosine (m6A) methylation on RNA transcripts.
Lee O. Vaasjo, Lee O. Vaasjo
doaj +2 more sources
Expression of distinct RNAs from 3′ untranslated regions [PDF]
Nucleic Acids Research, 2010 The 3' untranslated regions (3'UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of 3'UTRs in human, mouse and fly are also expressed separately from the associated protein-coding sequences to which they are normally linked, likely by post-transcriptional cleavage.
T. Mercer +12 more
openaire +8 more sources
Challenging the Roles of NSP3 and Untranslated Regions in Rotavirus mRNA Translation. [PDF]
PLoS ONE, 2016 Rotavirus NSP3 is a translational surrogate of the PABP-poly(A) complex for rotavirus mRNAs. To further explore the effects of NSP3 and untranslated regions (UTRs) on rotavirus mRNAs translation, we used a quantitative in vivo assay with simultaneous ...
Matthieu Gratia +8 more
doaj +3 more sources
Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy [PDF]
Frontiers in ImmunologyBackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy.
Christopher C. T. Sng +7 more
doaj +2 more sources
Ciphers and Executioners: How 3′-Untranslated Regions Determine the Fate of Messenger RNAs [PDF]
Frontiers in Genetics, 2019 The sequences and structures of 3′-untranslated regions (3′UTRs) of messenger RNAs govern their stability, localization, and expression. 3′UTR regulatory elements are recognized by a wide variety of trans-acting factors that include microRNAs (miRNAs ...
Vinay K. Mayya, Thomas F. Duchaine
doaj +3 more sources
Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia. [PDF]
Int J Mol Sci, 2023 Before the advent of next-generation sequencing, research on acute myeloid leukemia (AML) mostly centered on protein-coding genes. In recent years, breakthroughs in RNA sequencing technologies and whole transcriptome analysis have led to the discovery ...
Yeh SC, Cheong FJF, Tay Y.
europepmc +2 more sources
The role of noncoding genetic variants in cardiomyopathy
Frontiers in Cardiovascular Medicine, 2023 Cardiomyopathies remain one of the leading causes of morbidity and mortality worldwide. Environmental risk factors and genetic predisposition account for most cardiomyopathy cases.
Myo Htet +7 more
doaj +1 more source