Genome MedicineBackground Both promoters and untranslated regions (UTRs) have critical regulatory roles, yet variants in these regions are largely excluded from clinical genetic testing due to difficulty in interpreting pathogenicity.
Alexandra C. Martin-Geary +24 more
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Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.
PLoS ONE, 2014 Eukaryotic cells control their growth and morphogenesis to maintain integrity and viability. Free-living cells are further challenged by their direct interaction with the environment and in many cases maintain a resilient cell wall to stay alive under ...
Antony G Wanless, Yuan Lin, Eric L Weiss
doaj +1 more source
The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity
Frontiers in Microbiology, 2018 Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute ...
Anna Kloc +2 more
doaj +1 more source
Removal of 5 '- and 3 '-untranslated regions enhances erythropoietin gene expression in mammalian cells [PDF]
, 2001 The effect of the 5′-and 3′-untranslated regions (UTR) of human erythropoietin gene (gEpo) on its expression in mammalian cells was investigated. 5′-UTR-deleted, 3′-UTR-deleted, and 5′,3′-UTR-deleted gEpos were transfected into COS-7 cells, and the ...
W B Kim +5 more
core +1 more source
DataSheet1_Identification and Cross-Characterisation of Artificial Promoters and 5′ Untranslated Regions in Vibrio natriegens.ZIP [PDF]
, 2022 Vibrio natriegens has recently gained attention as a novel fast-growing bacterium in synthetic biology applications. Currently, a limited set of genetic elements optimised for Escherichia coli are used in V.
Maria W. Hoff (12008660) +3 more
core +1 more source
Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Advanced Materials, EarlyView.Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
UTRdb and UTRsite (RELEASE 2010) : a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs [PDF]
, 2010 The 5' and 3' untranslated regions of eukaryotic mRNAs (UTRs) play crucial roles in the post-transcriptional regulation of gene expression through the modulation of nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and ...
V. A. Gennarino +12 more
core +3 more sources
The untranslated regions of classic swine fever virus RNA trigger apoptosis.
PLoS ONE, 2014 Classical swine fever virus (CSFV) causes a broad range of disease in pigs, from acute symptoms including high fever and hemorrhages, to chronic disease or unapparent infection, depending on the virus strain.
Wei-Li Hsu +7 more
doaj +1 more source
Cell Reports, 2020 Summary: Bacterial pathogens often employ RNA regulatory elements located in the 5′ untranslated regions (UTRs) to control gene expression. Using a comparative structural analysis, we examine the structure of 5′ UTRs at a global scale in the pathogenic ...
Dmitriy Ignatov +10 more
doaj +1 more source
Discovery of regulatory motifs in 5′ untranslated regions using interpretable multi-task learning models [PDF]
, 2023 The sequence in the 5′ untranslated regions (UTRs) is known to affect mRNA translation rates. However, the underlying regulatory grammar remains elusive.
Ho, Joshua W K +6 more
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