Results 221 to 230 of about 82,838 (255)
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UPLC-MS/MS determination of doxazosine in human plasma
Analytical and Bioanalytical Chemistry, 2006A sensitive, selective and rapid method for the analysis of doxazosine (DOX) in human plasma based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) is described. DOX and tamsulosin, used as an internal standard (IS), were extracted by liquid-liquid extraction, and the chromatography was performed on a C18 UPLC column ...
Osama Y, Al-Dirbashi +4 more
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Pharmacokinetics and bioavailability of gelsenicine in mice by UPLC–MS/MS
Biomedical Chromatography, 2018AbstractGelsenicine is an indole alkaloid isolated from Gelsemium elegans Benth. In recent years, the role of G. elegans Benth preparations in anti‐tumor, analgesic, dilatation and dermatological treatment has attracted attention, and it has been applied clinically, but it is easy to cause poisoning with its use. An UPLC–MS/MS method was established to
Jianbo Li +5 more
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Quantification of Tricyclic Antidepressants Using UPLC-MS/MS
2012Depression is a psychiatric condition that affects about 120 million people worldwide and can interfere with independence and productivity in essentially all aspects of daily life. Depression is also associated with risk of self-harm, and ultimately suicide. Antidepressant medications are widely used to treat symptoms of depression.
Kamisha L, Johnson-Davis +3 more
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Simultaneous monitoring of pazopanib and its metabolites by UPLC–MS/MS
Journal of Pharmaceutical and Biomedical Analysis, 2018Pazopanib is a multi-targeted tyrosine kinase inhibitor (TKI) approved as first-line treatment for patients with advanced renal cell carcinoma (RCC) and as second-line treatment for patients with advanced soft tissue sarcoma (STS) previously treated with chemotherapy.
Paludetto, M. N.; id_orcid 0000-0002-8053-6889 +6 more
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Pharmacokinetics of yunaconitine and indaconitine in mouse blood by UPLC-MS/MS
Journal of Chromatography B, 2021Yunaconitine and indaconitine are active ingredients from the rhizomes of Aconitum plants. In this study, an ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed to measure the concentrations of the yunaconitine and indaconitine in mouse blood, and the method was applied in measuring the ...
Xiaomin, Yu +5 more
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Rapid Communications in Mass Spectrometry, 2010
Abstract Fast and efficient ultra‐performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) analysis of short interfering RNA oligonucleotides was used for identity confirmation of the target sequence‐related impurities. Multiple truncated oligonucleotides and metabolites were identified based on the
Vera B, Ivleva +2 more
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Abstract Fast and efficient ultra‐performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) analysis of short interfering RNA oligonucleotides was used for identity confirmation of the target sequence‐related impurities. Multiple truncated oligonucleotides and metabolites were identified based on the
Vera B, Ivleva +2 more
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UPLC-MS/MS investigation of β-glucan oligosaccharide oxidation
The Analyst, 2016Fenton-induced degradation of isomeric β-d-glucotetraoses is systematically investigated by negative mode HILIC UPLC-MS/MS with regard to the effect of the glycosidic linkage on kinetics, product profiles, and MS/MS fragmentation patterns.
Boulos S, Nyström L
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An UPLC–MS/MS method for the quantitation of alectinib in rat plasma
Journal of Pharmaceutical and Biomedical Analysis, 2017Currently, crizotinib is the first generation drug, which has been used in the treatment of ALK-rearranged non-small cell lung cancer (NSCLC). However, more and more patients are found in crizotinib-resistance. In the last year, alectinib has been approved for treatment of patients with crizotinib-resistance.
Xiang-Xin, Huang +5 more
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Global metabolic profiling procedures for urine using UPLC–MS
Nature Protocols, 2010The production of 'global' metabolite profiles involves measuring low molecular-weight metabolites (
Elizabeth J, Want +7 more
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Determination of ergot alkaloids from grains with UPLC‐MS/MS
Journal of Separation Science, 2010AbstractA simple and rapid method for determining six ergot alkaloids and four of their respective epimers was developed for rye and wheat. The analytes were extracted from the sample matrix with ACN/ammonium carbonate solution. The extract was purified with a commercial push‐through SPE column (Mycosep® 150 Ergot).
Meri, Kokkonen, Marika, Jestoi
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