Results 11 to 20 of about 597,523 (235)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Optimal path planning for surveillance with temporal-logic constraints [PDF]
, 2011 In this paper we present a method for automatically generating optimal robot paths satisfying high-level mission specifications. The motion of the robot in the environment is modeled as a weighted transition system.
Belta, Calin +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2018 Part 1 of assignment - Authoring your critical discourse analysis on zombies (Essay 3): 800-word essay that examines language and communication as used in Max Brooks’ novel World War Z.
Thomas, Jamie A.
core +1 more source
Singularities and K-semistability
, 2010 In this paper we extend the notion of Futaki invariant to big and nef classes in such a way that it defines a continuous function on the \K\ cone up to the boundary. We apply this concept to prove that reduced normal crossing singularities are sufficient
Alberto Della Vedova +20 more
core +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
On Resource Aware Algorithms in Epidemic Live Streaming [PDF]
, 2009 Epidemic-style diffusion schemes have been previously proposed for achieving peer-to-peer live streaming. Their performance trade-offs have been deeply analyzed for homogeneous systems, where all peers have the same upload capacity.
Mathieu, Fabien, Perino, Diego
core +6 more sources
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Machine Learning Playground [PDF]
, 2018 Machine learning is a science that “learns” about the data by finding unique patterns and relations in the data. There are a lot of libraries or tools available for processing machine learning datasets.
Khan, Adil
core +1 more source